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Found 70 with Last Name = 'hibert' and Initial = 'mf'
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50000483((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)
Affinity DataKi:  0.589nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  0.603nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor entirely in guinea pig ileumMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  1nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  1.40nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  3.31nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heartMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50000483((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82561(CAS_40796-97-2 | TROPANYL 3,5-DICHLOROBENZOATE | T...)
Affinity DataKi:  55nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM48320(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)
Affinity DataKi:  200nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor entirely in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM48320(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)
Affinity DataKi:  229nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421836(CHEMBL12129)
Affinity DataIC50:  0.631nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  0.794nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor in rat frontal cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataIC50:  3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421834(CHEMBL12311)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421837(CHEMBL273490)
Affinity DataIC50:  5.60nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor in rat frontal cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50154716((-)-1-Methyl-4-(8-methylsulfanyl-10,11-dihydro-dib...)
Affinity DataIC50:  6.30nMAssay Description:Apparent inhibition constant (Ki) for cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421836(CHEMBL12129)
Affinity DataIC50:  10nMAssay Description:Binding affinity against Dopamine receptor D2 in rat brain membrane using [3H]-8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  16nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50:  22nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  63nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421836(CHEMBL12129)
Affinity DataIC50:  79nMAssay Description:Binding affinity against Dopamine receptor D2 in rat brain membrane using [3H]-8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50154716((-)-1-Methyl-4-(8-methylsulfanyl-10,11-dihydro-dib...)
Affinity DataIC50:  95nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataIC50:  123nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  158nMAssay Description:Binding affinity against Dopamine receptor D2 in rat brain membrane using [3H]-8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421834(CHEMBL12311)
Affinity DataIC50:  158nMAssay Description:Binding affinity against Dopamine receptor D2 in rat brain membrane using [3H]-8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421834(CHEMBL12311)
Affinity DataIC50:  158nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM36108((R)-propranolol)
Affinity DataIC50:  170nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50154716((-)-1-Methyl-4-(8-methylsulfanyl-10,11-dihydro-dib...)
Affinity DataIC50:  182nMAssay Description:Binding affinity towards 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421836(CHEMBL12129)
Affinity DataIC50:  200nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421839(CHEMBL11824)
Affinity DataIC50:  316nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421838(CHEMBL11787)
Affinity DataIC50:  316nMAssay Description:Binding affinity against Dopamine receptor D2 in rat brain membrane using [3H]-8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421834(CHEMBL12311)
Affinity DataIC50:  398nMAssay Description:Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  398nMAssay Description:Inhibition of human placental cytochrome P450 19A1 androstenedioneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM36108((R)-propranolol)
Affinity DataIC50:  490nMAssay Description:Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50421836(CHEMBL12129)
Affinity DataIC50:  501nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  631nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  631nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  631nMAssay Description:Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421838(CHEMBL11787)
Affinity DataIC50:  794nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  794nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421836(CHEMBL12129)
Affinity DataIC50:  794nMAssay Description:Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421834(CHEMBL12311)
Affinity DataIC50:  794nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421837(CHEMBL273490)
Affinity DataIC50:  851nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421838(CHEMBL11787)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human placental cytochrome P450 19A1 androstenedioneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421835(CHEMBL12124)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50421838(CHEMBL11787)
Affinity DataIC50:  3.16E+3nMAssay Description:Binding affinity against 5-HT1B receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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