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Found 1416 with Last Name = 'hornberger' and Initial = 'w'
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345133((S)-1-((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-y...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345134((S)-1-((R)-5-chloro-3-(2-methoxy-5-((4-methylpiper...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345131((S)-1-((R)-5-chloro-3-(2-methoxy-4-((4-methylpiper...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345130((S)-1-((R)-5-chloro-3-(2-methoxy-4-(pyrrolidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202249(US9238619, 12)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202260(US9238619, 18)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202265(US9238619, 23)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202266(US9238619, 24)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202270(US9238619, 28)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202271(US9238619, 29)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202272(US9238619, 30)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202273(US9238619, 31)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202274(US9238619, 32)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202275(US9238619, 33)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202315(US9238619, 51)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202316(US9238619, 52)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202334(US9238619, 59)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202335(US9238619, 60)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202336(US9238619, 61)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202337(US9238619, 62)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202341(US9238619, 63)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202348(US9238619, 67)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202351(US9238619, 70)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202353(US9238619, 72)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202356(US9238619, 73)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202358(US9238619, 75)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202359(US9238619, 76)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202361(US9238619, 78)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202314(US9238619, 50)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202247(US9238619, 10)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202241(US9238619, 6)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202240(US9238619, 5)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202238(US9238619, 3)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

US Patent
LigandPNGBDBM202239(US9238619, 4)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council of Canada

Curated by ChEMBL
LigandPNGBDBM50004744(CHEMBL2370453 | Hirudin analogue)
Affinity DataKi:  0.140nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345132((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council of Canada

Curated by ChEMBL
LigandPNGBDBM50004739(CHEMBL2370455 | Hirudin analogue)
Affinity DataKi:  0.370nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175477(3-{2-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175489(7-methyl-3-[2-(4-naphthalen-1-yl-piperazin-1-yl)-e...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175463(3-{2-[4-(3-chloro-2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175467(3-[2-(4-isoquinolin-1-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council of Canada

Curated by ChEMBL
LigandPNGBDBM50004745(CHEMBL2370450 | Hirudin analogue)
Affinity DataKi:  0.560nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175477(3-{2-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175460(3-{2-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-ethy...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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