Affinity DataKi: 0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.0400nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland
US Patent
Abbvie Deutschland
US Patent
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.370nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 0.560nMAssay Description:Compound was evaluated for their ability to inhibit the alpha-thrombin-mediated hydrolysis of the fluorescent substrate Tos-Gly-Pro-Arg-AmcMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair