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Found 2225 with Last Name = 'hornsperger' and Initial = 'b'
TargetMonoglyceride lipase(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM597927(US11608347, Example 55 | [(7R,9aR)-7-(3-chloro-4- ...)
Affinity DataIC50:  0.200nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496984(US11001555, Example 7)
Affinity DataIC50:  0.262nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM475923((4S)-4-[[(2S)-2-[[(2R)-2- (3-chloro-5- cyanophenox...)
Affinity DataIC50:  0.293nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514094(US11059858, Example 48)
Affinity DataIC50:  0.300nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514076(US11059858, Example 33)
Affinity DataIC50:  0.300nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514085(US11059858, Example 42)
Affinity DataIC50:  0.300nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496983(US11001555, Example 6)
Affinity DataIC50:  0.351nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514104(US11059858, Example 58)
Affinity DataIC50:  0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514098(N-[(2S)-3-(3-Chlorophenyl)-1-[[(1S)-2-[[(3S)-5,5-d...)
Affinity DataIC50:  0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514090(US11059858, Example 44)
Affinity DataIC50:  0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514091(US11059858, Example 45)
Affinity DataIC50:  0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514056(US11059858, Example 15)
Affinity DataIC50:  0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499311(US11014963, Example 216)
Affinity DataIC50:  0.400nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50569654(CHEMBL4875383 | US11802133, Example 239)
Affinity DataIC50:  0.400nMAssay Description:The 4-NPA assay was carried out in 384 well assay plates (black with clear bottom, non-binding surface treated, Corning Ref. 3655) in a total volume ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM475927((4S)-4-[[(2S)-2-[[(2R)-2- (3-chlorophenoxy)-3-(3- ...)
Affinity DataIC50:  0.461nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496981(US11001555, Example 4)
Affinity DataIC50:  0.471nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499107(US11014963, Example 17)
Affinity DataIC50:  0.490nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514086(US11059858, Example 43)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50541792(CHEMBL4635011)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human CYP11B2 expressed in human renal leiomyoblastoma cells harboring FDXR/FDX using 1-deoxycorticosterone as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514058(US11059858, Example 17)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514075(US11059858, Example 32)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514061(US11059858, Example 20)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514057(US11059858, Example 16)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514077(US11059858, Example 34)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514078(US11059858, Example 35)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514102(US11059858, Example 56)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499266(US11014963, Example 166)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514079(US11059858, Example 36)
Affinity DataIC50:  0.5nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496990(US11001555, Example 13)
Affinity DataIC50:  0.538nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM476636(US10870623, Example 8)
Affinity DataIC50:  0.550nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496997(N-[(2S)-3-(3,4-Dichlorophenyl)-1-[(2S,4R)-2-[[(3S)...)
Affinity DataIC50:  0.574nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496982(US11001555, Example 5)
Affinity DataIC50:  0.579nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514063(US11059858, Example 22)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514084((4S)-4-[[(2S)-2-[[(2S)-3-(3-Chlorophenyl)-2-[[2-(3...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514099(3,5-Dichloro-N-[(2S)-3-(3-chlorophenyl)-1-[[(1S)-2...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514101(US11059858, Example 55)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514103(US11059858, Example 57)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499267(US11014963, Example 170)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514059(US11059858, Example 18)
Affinity DataIC50:  0.600nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499264(US11014963, Example 163)
Affinity DataIC50:  0.602nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499095(US11014963, Example 6)
Affinity DataIC50:  0.620nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499097(US11014963, Example 8)
Affinity DataIC50:  0.620nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496994(US11001555, Example 17)
Affinity DataIC50:  0.667nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM475926((4S)-4-[[(2S)-2-[[(2R)-2- (3-cyanophenoxy)-3-(3- f...)
Affinity DataIC50:  0.686nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM496988(US11001555, Example 11)
Affinity DataIC50:  0.694nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499222((2S)-3-(3-Chlorophenyl)-2-[[2-(3-chlorophenyl)acet...)
Affinity DataIC50:  0.695nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM514093(US11059858, Example 47)
Affinity DataIC50:  0.700nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499291((2S)-2-[[2-(2,5-Dichlorophenyl)-2,2-difluoroacetyl...)
Affinity DataIC50:  0.700nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50569652(CHEMBL4874643 | US11802133, Example 221)
Affinity DataIC50:  0.700nMAssay Description:The 4-NPA assay was carried out in 384 well assay plates (black with clear bottom, non-binding surface treated, Corning Ref. 3655) in a total volume ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease HTRA1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM499179(US11014963, Example 73)
Affinity DataIC50:  0.710nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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