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Found 134 with Last Name = 'huang' and Initial = 'jc'
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86492(CAS_170713-75-4 | NSC_6324645 | Nociceptin)
Affinity DataKi:  0.180nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86491(DiPOA | [8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,...)
Affinity DataKi:  0.760nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86258(CAS_23552-18-3 | Morphine | NSC_5980)
Affinity DataKi:  2.06nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86493(CAS_27943 | NALTREXONE-HCl | NSC_27943 | Naltrexon...)
Affinity DataKi:  2.39nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  3.69nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86258(CAS_23552-18-3 | Morphine | NSC_5980)
Affinity DataKi:  134nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86491(DiPOA | [8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,...)
Affinity DataKi:  243nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86491(DiPOA | [8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,...)
Affinity DataKi:  286nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86260(CAS_465-65-6 | NALOXONE | NSC_10064 | Naloxone(-))
Affinity DataKi:  488nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86258(CAS_23552-18-3 | Morphine | NSC_5980)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM86258(CAS_23552-18-3 | Morphine | NSC_5980)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  5nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-9 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414894(CHEMBL573760)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  7nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-7 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  7nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052635(5,6,7-Trichloro-1H-quinoline-2,3,4-trione 3-oxime ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414893(CHEMBL578426)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066544(4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol | CHEMBL...)
Affinity DataIC50:  8nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052629(6,7-Dichloro-1H-quinoline-2,3,4-trione 3-oxime | C...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066538(4-[3-(4-Phenyl-butylamino)-propyl]-phenol | CHEMBL...)
Affinity DataIC50:  15nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  18nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-6 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414892(CHEMBL576168)
Affinity DataIC50:  19.9nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052627(5,6,7-Trichloro-1,4-dihydro-quinoxaline-2,3-dione ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414891(CHEMBL574005)
Affinity DataIC50:  31.6nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052625(5,7-Dichloro-1H-quinoline-2,3,4-trione 3-oxime | C...)
Affinity DataIC50:  33nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066547(4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol | CHEMBL4...)
Affinity DataIC50:  35nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052626(5,7-Dimethyl-1H-quinoline-2,3,4-trione 3-oxime | C...)
Affinity DataIC50:  37nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066539(4-[2-(4-Phenyl-butylamino)-ethyl]-phenol | CHEMBL1...)
Affinity DataIC50:  43nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066546(4-[3-(5-Phenyl-pentylamino)-propyl]-phenol | CHEMB...)
Affinity DataIC50:  45nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414895(CHEMBL578836)
Affinity DataIC50:  50.1nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052631(7-Chloro-1H-quinoline-2,3,4-trione 3-oxime | CHEMB...)
Affinity DataIC50:  53nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414890(CHEMBL565272)
Affinity DataIC50:  63.1nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414889(CHEMBL574443)
Affinity DataIC50:  63.1nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366934(CHEMBL1794026)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414888(CHEMBL583635)
Affinity DataIC50:  79.4nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066543(4-[2-(3-Phenyl-propylamino)-ethyl]-phenol | CHEMBL...)
Affinity DataIC50:  96nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140551(3-((S)-2-Benzyloxycarbonylamino-2-phenyl-acetylami...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140552(3-((S)-2-Benzyloxycarbonylamino-butyrylamino)-5-fl...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140549(3-((S)-2-Benzyloxycarbonylamino-2-cyclohexyl-acety...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  120nMAssay Description:Compound was evaluated for its inhibitory activity against the Calpain-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414887(CHEMBL574209)
Affinity DataIC50:  126nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM22778(6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione | 6...)
Affinity DataIC50:  130nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140550(3-((S)-2-Benzyloxycarbonylamino-3-thiophen-2-yl-pr...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50052621(5,6-Dichloro-1H-quinoline-2,3,4-trione 3-oxime | C...)
Affinity DataIC50:  170nMAssay Description:Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066545(4-[(1S,2R)-1-Hydroxy-2-((R)-1-methyl-3-phenyl-prop...)
Affinity DataIC50:  180nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140544(3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50066541(4-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-phenol; hydr...)
Affinity DataIC50:  200nMAssay Description:Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50414886(CHEMBL573763)
Affinity DataIC50:  200nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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