Compile Data Set for Download or QSAR
maximum 50k data
Found 649 with Last Name = 'humblet' and Initial = 'c'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM430(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  0.0300nM ΔG°:  -62.5kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2208((6S)-3-{[2-tert-butyl-4-(hydroxymethyl)-5-methylph...)
Affinity DataKi:  0.0900nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2204((3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsu...)
Affinity DataKi:  0.0900nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045284(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045281(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2206((6S)-6-[2-(4-aminophenyl)ethyl]-3-{[2-tert-butyl-4...)
Affinity DataKi:  0.110nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2533(3-{[2-tert-butyl-4-(hydroxymethyl)-5-methylphenyl]...)
Affinity DataKi:  0.170nM ΔG°:  -58.0kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008856(2-Methyl-acenaphthene-1-carboxylic acid methyl-(7-...)
Affinity DataKi:  0.370nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045290(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2536(6-Alkyl-6-phenethyldihydropyrone 13y | 6-[2-(4-ami...)
Affinity DataKi:  0.430nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045290(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50008139(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50072740((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory activity of the compound towards ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045285(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045291(CHEMBL88340 | i2-[2-(Morpholine-4-sulfonylamino)-3...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008858(2-Benzofuran-4-yl-N-methyl-N-(7-pyrrolidin-1-yl-1-...)
Affinity DataKi:  0.830nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity,determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50008139(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity against human gastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM448(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  1.10nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008852(2-Methyl-acenaphthene-1-carboxylic acid (7-imidazo...)
Affinity DataKi:  1.20nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045281(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045285(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045292((S)-2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045287(CHEMBL88526 | N-[Allylsulfanyl-(1-cyclohexylmethyl...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045284(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045283(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008857(CHEMBL543329 | N-Methyl-2-naphthalen-1-yl-N-(7-pyr...)
Affinity DataKi:  3.40nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity,determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50072736((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity of the compound towards ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(2-Benzo[b]thiophen-4-yl-N-methyl-N-(2-pyrrolidin-1...)
Affinity DataKi:  3.70nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045282(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045283(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  6.10nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045292((S)-2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human gastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045290(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  9nMAssay Description:Binding affinity against human gastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  10nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50008139(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  11nMAssay Description:Binding affinity against human pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/molepH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008855(4,5-Dihydro-3H-naphtho[1,8-bc]thiophene-5-carboxyl...)
Affinity DataKi:  11nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045282(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  11nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008855(4,5-Dihydro-3H-naphtho[1,8-bc]thiophene-5-carboxyl...)
Affinity DataKi:  11.1nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045288(CHEMBL329220 | N-(1-Cyclohexylmethyl-2,4-dihydroxy...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045292((S)-2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045284(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human gastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045289(6-(3-Methyl-thioureido)-2-[2-(morpholine-4-sulfony...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045287(CHEMBL88526 | N-[Allylsulfanyl-(1-cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045285(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  16nMAssay Description:Binding affinity against human pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045292((S)-2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl...)
Affinity DataKi:  17nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50008139(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  18nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2166((3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsu...)
Affinity DataKi:  18.4nM ΔG°:  -45.9kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045281(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  19nMAssay Description:Binding affinity against human gastricsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045291(CHEMBL88340 | i2-[2-(Morpholine-4-sulfonylamino)-3...)
Affinity DataKi:  21nMAssay Description:Binding affinity against human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50045290(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  24nMAssay Description:Binding affinity against human pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 649 total ) | Next | Last >>
Jump to: