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Found 273 with Last Name = 'islam' and Initial = 'k'
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153127(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153124(CHEMBL182967 | N-(2-{1-[1-(4-Isopropyl-cyclohexyl)...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153121(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153132(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  8nM ΔG°:  -47.0kJ/mole IC50:  50nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Streptococcus pneumoniae (ATCC49619))
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  9nM ΔG°:  -46.7kJ/mole IC50:  90nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153135(1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153137(3-Butyl-1-[1-(4-isopropyl-cyclohexyl)-piperidin-4-...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153131(CHEMBL185415 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  25nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Streptococcus pneumoniae)
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  27nM ΔG°:  -43.9kJ/mole IC50:  50nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153129(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-3...)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153131(CHEMBL185415 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  33nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  37nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153137(3-Butyl-1-[1-(4-isopropyl-cyclohexyl)-piperidin-4-...)
Affinity DataKi:  38nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Arpida

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  40nM ΔG°:  -42.9kJ/mole IC50:  600nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153123(1-[1-(1,4-Dimethyl-pentyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  40nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153125(CHEMBL364844 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  41nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153141(1-(1-Indan-2-yl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi:  46nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153122(CHEMBL181545 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  63nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153123(1-[1-(1,4-Dimethyl-pentyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  73nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153135(1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  83nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153132(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  86nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase [F98Y](Staphylococcus aureus (subsp. aureus NCTC 8325))
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  90nM ΔG°:  -40.9kJ/mole IC50:  900nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153127(2-{1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2...)
Affinity DataKi:  92nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153129(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-3...)
Affinity DataKi:  92nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153124(CHEMBL182967 | N-(2-{1-[1-(4-Isopropyl-cyclohexyl)...)
Affinity DataKi:  106nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153125(CHEMBL364844 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  182nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153128(1-(1-Cyclooctyl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi:  187nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153134(1-[1-(4-Propyl-cyclohexyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  188nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153121(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-...)
Affinity DataKi:  207nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153121(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-...)
Affinity DataKi:  207nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153126(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-1...)
Affinity DataKi:  225nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153134(1-[1-(4-Propyl-cyclohexyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi:  231nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Streptococcus pneumoniae)
Arpida

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  240nM ΔG°:  -38.4kJ/mole IC50:  3.00E+3nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153122(CHEMBL181545 | {1-[1-(4-Isopropyl-cyclohexyl)-pipe...)
Affinity DataKi:  289nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153148(1-(1-Naphthalen-2-ylmethyl-piperidin-4-yl)-3,4-dih...)
Affinity DataKi:  294nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153130(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  357nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153148(1-(1-Naphthalen-2-ylmethyl-piperidin-4-yl)-3,4-dih...)
Affinity DataKi:  609nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153141(1-(1-Indan-2-yl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi:  660nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153130(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  748nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153128(1-(1-Cyclooctyl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi:  1.38E+3nMAssay Description:Inhibition of [3H]diprenorphine binding to human Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153139(1-[1-(4-Benzyloxy-benzyl)-piperidin-4-yl]-3,4-dihy...)
Affinity DataKi:  1.88E+3nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153128(1-(1-Cyclooctyl-piperidin-4-yl)-3,4-dihydro-1H-ben...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153135(1-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-3,4-dih...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153140(1-[1-(1,2,3,4-Tetrahydro-naphthalen-2-yl)-piperidi...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153129(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-3...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153121(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50153142(1-(1-Biphenyl-4-ylmethyl-piperidin-4-yl)-1,3-dihyd...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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