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Found 678 with Last Name = 'iwanowicz' and Initial = 'e'
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.460nMAssay Description:Competitive kinetic for thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50280255(7-Amino-3-{[(S)-1-((R)-2-amino-3-phenyl-propionyl)...)
Affinity DataKi:  1.70nMAssay Description:Overall Inhibitory constant of the compound against thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pri

Curated by ChEMBL
LigandPNGBDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity of the compound against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  7nMAssay Description:Concentration of the compound required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107463((S)-1-((R)-2-Methanesulfonylamino-3-phenyl-propion...)
Affinity DataKi:  8.20nMAssay Description:Competitive kinetic for human alpha thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50039010((S)-2-[(S)-2-(4-Guanidino-butyrylamino)-3-phenyl-p...)
Affinity DataKi:  22nMAssay Description:Binding affinity for thrombin was reportedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50287156(2-Benzyl-1H-indole-5-carboxamidine | CHEMBL287401)
Affinity DataKi:  260nMAssay Description:Compound was evaluated for inhibition of human alpha-thrombin catalytic activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50:  0.00800nMAssay Description:Concentration of the compound required to inhibit thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50:  0.00800nMAssay Description:Concentration of the compound required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  0.0300nMAssay Description:Concentration of the compound required to inhibit thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  0.0450nMAssay Description:Concentration of the compound required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50:  0.230nMAssay Description:Concentration of the compound required to inhibit Plasmin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >0.5nMAssay Description:Inhibition of Lyn kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50:  0.700nMAssay Description:Concentration of the compound required to inhibit tissue-type plasminogen activator (t-PA) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120101((2-Chloro-6-methyl-phenyl)-[8-(4-methyl-piperazin-...)
Affinity DataIC50:  1nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120116(CHEMBL108362 | N*4*-(2-Chloro-6-methyl-phenyl)-N*7...)
Affinity DataIC50:  1.70nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50112911((2-Chloro-6-methyl-phenyl)-(6,7-dimethoxy-imidazo[...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against hydrolysis of human alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120094((2-Chloro-6-methyl-phenyl)-(7,8-dimethoxy-imidazo[...)
Affinity DataIC50:  2nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120087((2-Chloro-6-methyl-phenyl)-[8-(4-ethyl-piperazin-1...)
Affinity DataIC50:  2nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120090(CHEMBL108686 | N*4*-(2-Chloro-6-methyl-phenyl)-N*8...)
Affinity DataIC50:  2nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against hydrolysis of thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380371(CHEMBL2017970)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120125((2-Chloro-6-methyl-phenyl)-[8-methoxy-7-(2-morphol...)
Affinity DataIC50:  2.40nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50112947((6,7-Dimethoxy-imidazo[1,5-a]quinoxalin-4-yl)-(2,6...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120097((7,8-Dimethoxy-imidazo[1,5-a]quinoxalin-4-yl)-(2,6...)
Affinity DataIC50:  2.40nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380366(CHEMBL2017965)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380369(CHEMBL2017968)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >2.80nMAssay Description:Inhibition of Fgr protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120127(CHEMBL106213 | N*4*-(2-Chloro-6-methyl-phenyl)-N*7...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120109((2-Chloro-6-methyl-phenyl)-(8-methoxy-imidazo[1,5-...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120128(CHEMBL325986 | N*4*-(2-Chloro-6-methyl-phenyl)-N*8...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120093((2-Chloro-6-methyl-phenyl)-(8-piperazin-1-yl-imida...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50199036(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120089((2-Chloro-6-methyl-phenyl)-[8-(3,5-dimethyl-pipera...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120130(CHEMBL110732 | N-(4-(2-chloro-6-methylphenylamino)...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120113((2-chloro-6-methyl-phenyl)-(7,9-dioxa-2,5,10b-tria...)
Affinity DataIC50:  4nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120104(4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]qu...)
Affinity DataIC50:  4nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120111((2-Chloro-6-methyl-phenyl)-(8-morpholin-4-yl-imida...)
Affinity DataIC50:  4nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380367(CHEMBL2017966)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50112938((E)-4-(2-chloro-6-methylphenylamino)-6,7-dimethoxy...)
Affinity DataIC50:  4.30nMAssay Description:Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50:  4.60nMAssay Description:Concentration of the compound required to inhibit Coagulation factor X was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >4.70nMAssay Description:Inhibition of Yes kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120108(CHEMBL326476 | N*4*-(2-Chloro-6-methyl-phenyl)-N*8...)
Affinity DataIC50:  5nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120115(CHEMBL321862 | N*4*-(2-Chloro-6-fluoro-phenyl)-N*7...)
Affinity DataIC50:  5nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pri

Curated by ChEMBL
LigandPNGBDBM50123321(7-Methoxy-6-oxazol-5-yl-2-m-tolyl-1H-quinolin-4-on...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pri

Curated by ChEMBL
LigandPNGBDBM50123333(2-(4-Bromo-phenyl)-7-methoxy-6-oxazol-5-yl-1H-quin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pri

Curated by ChEMBL
LigandPNGBDBM50123358(7-Methoxy-2-(4-methyl-3-morpholin-4-yl-phenyl)-6-o...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pri

Curated by ChEMBL
LigandPNGBDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: <5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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