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Found 4265 with Last Name = 'jiang' and Initial = 'b'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM249277(US10017501, Compound 1020-18 | US9458145, 1020-18)
Affinity DataKi:  3.80nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain2 after 60 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM249277(US10017501, Compound 1020-18 | US9458145, 1020-18)
Affinity DataKi:  7.5nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after 60 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193770(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-oxopropyl)pi...)
Affinity DataKi:  11nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM249277(US10017501, Compound 1020-18 | US9458145, 1020-18)
Affinity DataKi:  16nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  18nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  19nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  20nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membrane; 19.5+/-12.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50195903(4-((2-methylquinolin-4-yl)methoxy)-N-((2,4,6-triox...)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  31nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  32nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  34nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  34nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  35nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  35nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  39nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193760(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  40nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  42nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193769(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-fluoroethyl)...)
Affinity DataKi:  49nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50195903(4-((2-methylquinolin-4-yl)methoxy)-N-((2,4,6-triox...)
Affinity DataKi:  50nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193781(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  50nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataKi:  61nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193759(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  69nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKi:  94nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain2 after 60 mins by HTR...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  95nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193779(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-methylpiperidin...)
Affinity DataKi:  96nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50195904(4-(2-methyl-quinolin-4-ylmethoxy)-N-(1,3,5-trioxo-...)
Affinity DataKi:  110nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50366924(CHEMBL609539)
Affinity DataKi:  117nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membrane; 117+/-46More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193777(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(cyclopropylmet...)
Affinity DataKi:  117nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  119nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50195917(4-(2-methyl-quinolin-4-ylmethoxy)-N-[6,8,10-trioxo...)
Affinity DataKi:  130nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193765(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  157nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50452006(CHEMBL610371)
Affinity DataKi:  158nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membrane; 158+/-21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKi:  163nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451992(CHEMBL609537)
Affinity DataKi:  165nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451996(CHEMBL608020)
Affinity DataKi:  166nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membrane; 166+/-75More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193765(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  166nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451986(CHEMBL608343)
Affinity DataKi:  192nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50195905(CHEMBL240464 | N-((5-ethyl-2,4,6-trioxo-hexahydrop...)
Affinity DataKi:  200nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKi:  200nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after 60 mins by HTR...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50195905(CHEMBL240464 | N-((5-ethyl-2,4,6-trioxo-hexahydrop...)
Affinity DataKi:  210nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193775(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(3-hydroxypropy...)
Affinity DataKi:  212nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193771(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  217nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  219nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193776(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propionylpiperi...)
Affinity DataKi:  224nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  233nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193777(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(cyclopropylmet...)
Affinity DataKi:  251nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193779(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-methylpiperidin...)
Affinity DataKi:  257nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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