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Found 110 with Last Name = 'johansson' and Initial = 'e'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365495(CHEMBL1957460)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365481(CHEMBL1957367)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365487(CHEMBL1957375)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365484(CHEMBL1955881)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50209531((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365483(CHEMBL1957369)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365486(CHEMBL1957374)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365476(CHEMBL1957361)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365500(CHEMBL1957462)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020015(CHEMBL3287814)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365479(CHEMBL1957364)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020011(CHEMBL3287810)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020014(CHEMBL3287813)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365485(CHEMBL1957373)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365482(CHEMBL1957368)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020011(CHEMBL3287810)
Affinity DataIC50:  25nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365494(CHEMBL1957381)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365496(CHEMBL1957370)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31589(triaryl imidazole, 1)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020015(CHEMBL3287814)
Affinity DataIC50:  40nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019982(CHEMBL3287584)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365492(CHEMBL1957379)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020012(CHEMBL3287811)
Affinity DataIC50:  63nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365478(CHEMBL1957363)
Affinity DataIC50:  65nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365490(CHEMBL1957377)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019983(CHEMBL3287585)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019983(CHEMBL3287585)
Affinity DataIC50:  79nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365493(CHEMBL1957380)
Affinity DataIC50:  97nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020010(CHEMBL3287586)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020012(CHEMBL3287811)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365488(CHEMBL1957365)
Affinity DataIC50:  108nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020010(CHEMBL3287586)
Affinity DataIC50:  126nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020014(CHEMBL3287813)
Affinity DataIC50:  126nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Rattus norvegicus (rat))
University of Copenhagen

LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  127nMpH: 8.0 T: 2°CAssay Description:To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365489(CHEMBL1957376)
Affinity DataIC50:  144nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020013(CHEMBL3287812)
Affinity DataIC50:  158nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019982(CHEMBL3287584)
Affinity DataIC50:  158nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019979(CHEMBL3287833)
Affinity DataIC50:  200nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020022(CHEMBL3287821)
Affinity DataIC50:  251nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020020(CHEMBL3287819)
Affinity DataIC50:  251nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365477(CHEMBL1957362)
Affinity DataIC50:  315nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019979(CHEMBL3287833)
Affinity DataIC50:  316nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Copenhagen

LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  367nMpH: 8.0 T: 2°CAssay Description:To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365491(CHEMBL1957378)
Affinity DataIC50:  456nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50019976(CHEMBL3287827)
Affinity DataIC50:  501nMAssay Description:Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyroglutamylated RF-amide peptide receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020020(CHEMBL3287819)
Affinity DataIC50:  501nMAssay Description:Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365475(CHEMBL1957360)
Affinity DataIC50:  561nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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