Found 196 with Last Name = 'jovanovska' and Initial = 'a' TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7alpha incubated for 5 mins measured at 10 secs interval by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cellsMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 11nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells measured after 5 to 10 mins post compound washout by PatchXpress automated ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at -120 mV holding potential measured for 8 sec by patch-clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptorMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of NaV1.7 channel in human DRG neurons assessed as reduction of TTX-sensitive current by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of NaV1.7 channel in mouse DRG neurons assessed as reduction of TTX-sensitive current by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 129nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 134nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 136nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 142nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 215nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after hyperpolarization to -115 mV for 8s followed by 20ms p...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
