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Found 462 with Last Name = 'keats' and Initial = 'j'
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230294(CHEMBL4071740)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230211(CHEMBL4063126)
Affinity DataKi:  4.30nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  6.70nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230212(CHEMBL4084776)
Affinity DataKi:  7nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230213(CHEMBL4092526)
Affinity DataKi:  14nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230210(CHEMBL4090107)
Affinity DataKi:  16nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230209(CHEMBL4100272)
Affinity DataKi:  65nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Selcia

Curated by ChEMBL
LigandPNGBDBM50230293(CHEMBL4082253)
Affinity DataKi:  795nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062357(AP26113 | CHEMBL3397300)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185287(CHEMBL3823268)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185237(CHEMBL3824308)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50: <0.150nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185280(CHEMBL3822611)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185275(CHEMBL3823235)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <0.200nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human RET using KKKSPGEYVNIEFG by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50345579(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185284(CHEMBL3823549)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244622(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.230nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244621(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.230nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185281(CHEMBL3823416)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185268(CHEMBL3824327)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132351(({4-[6-(2,6-Dichloro-phenyl)-8-(3-dimethylamino-pr...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185290(CHEMBL3824304)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185283(CHEMBL3823603)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185286(CHEMBL3823256)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185272(CHEMBL3823107)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185278(CHEMBL3823017)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of ABL autophosphorylationMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185245(CHEMBL3823190)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185239(CHEMBL3823296)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185286(CHEMBL3823256)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185238(CHEMBL3823577)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50314074(2,6,9-Trisubstitute purine, 6 (AP23464) | 3-(2-(2-...)
Affinity DataIC50:  0.450nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50314074(2,6,9-Trisubstitute purine, 6 (AP23464) | 3-(2-(2-...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of 6x-His-tagged human Src kinase domain (T250 to L536 residues) expressed in Sf9 cells incubated for 2 hrs in presence of biotinylated cd...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50025051(CHEMBL461768)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244666(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50025051(CHEMBL461768)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244663(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244664(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50025052(CHEMBL517256)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50025052(CHEMBL517256)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244623(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244624(9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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