Affinity DataKi: 4nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 795nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: <0.150nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: <0.200nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human RET using KKKSPGEYVNIEFG by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] peptide substrate by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.230nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.230nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Inhibition of ABL autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.450nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of 6x-His-tagged human Src kinase domain (T250 to L536 residues) expressed in Sf9 cells incubated for 2 hrs in presence of biotinylated cd...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals
Curated by ChEMBL
Ariad Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair