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Found 3290 with Last Name = 'kim' and Initial = 'i'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021214(CHEMBL300019 | CHEMBL537996 | [3-(3,4-Dichloro-phe...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50371874(CHEMBL257733)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146042(1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol ...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146043(CHEMBL543372 | [(1R,3S)-3-(3,4-Dichloro-phenyl)-6-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021214(CHEMBL300019 | CHEMBL537996 | [3-(3,4-Dichloro-phe...)
Affinity DataKi:  1.10nMAssay Description:Displacement of from norepinephrine transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50054245(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 dosesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50054252(5-Bromo-N-cyclopropylmethyl-2-methyl-N-propyl-N'-(...)
Affinity DataKi:  2nMAssay Description:Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 dosesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  2nMAssay Description:Reuptake inhibitory activity against dopamine DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  2nMAssay Description:Reuptake inhibitory activity against Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50054250(CHEMBL306482 | N-Cyclopropylmethyl-2,5-dimethyl-N-...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 dosesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212359(CHEMBL558182 | threo-1-aza-4beta-hydroxy-5-(3,4-di...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50054248(2,5-Dimethyl-N,N-dipropyl-N'-(2,4,6-trichloro-phen...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 dosesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  3nMAssay Description:Reuptake inhibitory activity against Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50371872(CHEMBL257280)
Affinity DataKi:  3nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  3nMAssay Description:Reuptake inhibitory activity against dopamine DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021213(1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol |...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309848((R)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071729(CHEMBL313826 | Naphthalene-2-sulfonic acid [(S)-1-...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071723((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212365(CHEMBL556365 | threo-1-aza-5-(3,4-dichlorophenyl)[...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212361((1R,2R,9aR)-1-(3,4-dichlorophenyl)-2-ethyl-octahyd...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50054253(CHEMBL77716 | N-Cyclopropylmethyl-5-ethyl-2-methyl...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 dosesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212387(CHEMBL537653 | threo-3,4-dichlororitalinol hydroch...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212383((1R,2S,9aR)-1-(3,4-dichlorophenyl)-2-ethyl-octahyd...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50142840((R)-2-[(R)-(3,4-Dichloro-phenyl)-methoxycarbonyl-m...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50371868(CHEMBL269939)
Affinity DataKi:  5nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309847((S)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50371871(CHEMBL255112)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212373((1R,2S,9aR)-2-ethyl-1-phenyl-octahydro-1H-quinoliz...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071725((S)-3-(4-Aminomethyl-phenyl)-2-(anthracene-2-sulfo...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  6nMAssay Description:Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071722((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(6-me...)
Affinity DataKi:  6.60nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070783((S)-3-(4-Carbamimidoyl-phenyl)-N-cyclopentyl-N-met...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146043(CHEMBL543372 | [(1R,3S)-3-(3,4-Dichloro-phenyl)-6-...)
Affinity DataKi:  7nMAssay Description:Displacement of from norepinephrine transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146043(CHEMBL543372 | [(1R,3S)-3-(3,4-Dichloro-phenyl)-6-...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  9nMAssay Description:Displacement of from norepinephrine transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069055((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071726((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methy...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309845((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309837(1,3'-bipyrrolidin-1'-yl(4-((2-phenyl-1H-benzo[d]im...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50371866(CHEMBL257906)
Affinity DataKi:  10nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50212381(CHEMBL537874 | threo-1-aza-4beta-methoxy-5-phenyl[...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021213(1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol |...)
Affinity DataKi:  11nMAssay Description:Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  11nMAssay Description:Reuptake inhibitory activity against NE transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50071724((S)-3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(5-di...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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