Compile Data Set for Download or QSAR
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Found 51 with Last Name = 'kingston' and Initial = 'lp'
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.0955nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.100nM ΔG°:  -56.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.275nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.280nM ΔG°:  -54.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22009(5-{[(1R,3R)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  0.290nM ΔG°:  -53.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.302nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nM ΔG°:  -53.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.331nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.355nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.355nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22010(5-{[(1R,3S)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22011(5-{[(1S,3R,4S)-3,4-dihydroxycyclopentyl]sulfanyl}-...)
Affinity DataKi:  0.680nM ΔG°:  -51.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.708nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22025(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22014(5-{[(3R)-3-hydroxypyrrolidine-1-]sulfonyl}-3-methy...)
Affinity DataKi:  1.10nM ΔG°:  -50.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  1.17nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22004(3-methyl-1-(2-methylpropyl)-5-(propan-2-ylsulfanyl...)
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22008(5-{[(1R,2R)-2-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  2.70nM ΔG°:  -48.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22025(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22006(5-(cyclopentylsulfanyl)-3-methyl-1-(2-methylpropyl...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50416571(CHEMBL1221551)
Affinity DataKi:  3.39nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50416571(CHEMBL1221551)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22020(5-[(3-hydroxy-3-methylazetidin-1-yl)carbonyl]-3-me...)
Affinity DataKi:  3.5nM ΔG°:  -47.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22024(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(iso...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22026(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.70nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21985(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22015(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.90nM ΔG°:  -47.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22023(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  5.30nM ΔG°:  -46.8kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22017(3-methyl-1-(2-methylpropyl)-5-(pyrrolidin-1-ylcarb...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22017(3-methyl-1-(2-methylpropyl)-5-(pyrrolidin-1-ylcarb...)
Affinity DataKi:  5.5nM ΔG°:  -46.7kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22017(3-methyl-1-(2-methylpropyl)-5-(pyrrolidin-1-ylcarb...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22007(5-(cyclohexylsulfanyl)-3-methyl-1-(2-methylpropyl)...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22003(5-(ethylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-{[...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22025(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22012(5-[(2,3-dihydroxypropyl)sulfanyl]-3-methyl-1-(2-me...)
Affinity DataKi:  6.5nM ΔG°:  -46.3kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22027(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  6.60nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22018(3-methyl-1-(2-methylpropyl)-5-(piperidin-1-ylcarbo...)
Affinity DataKi:  8.70nM ΔG°:  -45.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22016(5-(azetidin-1-ylcarbonyl)-3-methyl-1-(2-methylprop...)
Affinity DataKi:  9.20nM ΔG°:  -45.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22013(5-{[(1R,3S)-3-hydroxycyclopentane]sulfonyl}-3-meth...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22005(5-(cyclobutylsulfanyl)-3-methyl-1-(2-methylpropyl)...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50031739(1-Isobutyl-3-methyl-6-naphthalen-1-ylmethyl-1,6-di...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22028(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50324668(6-[[4-azido-3-(iodo-125I)phenyl]methyl]-2,6-dihydr...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22029(6-[(4,5-dichloro-2-methyl-1H-imidazol-1-yl)methyl]...)
Affinity DataKi:  26nM ΔG°:  -42.9kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21985(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  30.9nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM21985(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM22019(N,N,3-trimethyl-1-(2-methylpropyl)-2,4-dioxo-6-{[2...)
Affinity DataKi:  37nM ΔG°:  -42.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50031739(1-Isobutyl-3-methyl-6-naphthalen-1-ylmethyl-1,6-di...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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