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Found 191 with Last Name = 'koblish' and Initial = 'hk'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300312(4-amino-1,2,5-oxadiazole-3-carboximidamide | CHEMB...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataKi:  3.40E+4nMAssay Description:Competitive inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14208(3-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50:  0.800nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529386(CHEMBL4458634)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529384(CHEMBL4438376)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50: <1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM261330(US10092570, Example 352 | US9707233, 350)
Affinity DataIC50: <1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: <1nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of poly(Glu:Tyr) by purified recombinant human FLT3. The extent of phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in AKT phosphorylation incubated for 2 hrs by Alexa flour 488 based FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]-ATP base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM261317(US10376513, Example 310 | US11433071, Example 311 ...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529381(CHEMBL4446120)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529385(CHEMBL4444112)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM384664(4-((5)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgE antibody-induced CD63 expression by flow cast kit methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529388(CHEMBL4443149)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529391(CHEMBL4513857)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14201(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-phenyl-7H-p...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004547(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529390(CHEMBL4470672)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14207(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-2-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529383(CHEMBL4570334)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14203(7-(3-methoxyphenyl)-N-[3-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
LigandPNGBDBM50529389(CHEMBL4440146)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14197(7-(3-methanesulfonylphenyl)-N-[4-(4-methylpiperazi...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14200(7-(3-methanesulfonylphenyl)-N-[3-(4-methylpiperazi...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233431(CHEMBL3979473 | US9789094, 5)
Affinity DataIC50:  11nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14205(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14193(4-[4-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-y...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14199(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14196(N-[4-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14202(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529382(CHEMBL4471294)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233424(CHEMBL4076756)
Affinity DataIC50:  14nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233430(CHEMBL3955791 | US11207302, Example 2)
Affinity DataIC50:  16nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300299(4-Amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiaz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233429(CHEMBL4083203)
Affinity DataIC50:  17nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14198(7-(2,3-dihydro-1H-inden-2-yl)-N-[4-(4-methylpipera...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300296(4-Amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadia...)
Affinity DataIC50:  19nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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