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Found 22 with Last Name = 'kolykhalov' and Initial = 'a'
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150593(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  6.10nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150591((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  22nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150599(2-{(S)-2-[(S)-2-Cyclohexyl-2-(2-2H-tetrazol-5-yl-a...)
Affinity DataKi:  30nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150595((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  31nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150606(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  65nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150602(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  74nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150604(2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetrazol-5...)
Affinity DataKi:  82nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150605(CHEMBL360805 | Naphthalene-2-carboxylic acid (S)-1...)
Affinity DataKi:  110nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150598((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  112nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150601(2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyrazine-2-car...)
Affinity DataKi:  123nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150594((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  170nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150607(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  193nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150590((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  248nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150597(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  271nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150600(CHEMBL360747 | Naphthalene-2-carboxylic acid (S)-5...)
Affinity DataKi:  400nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150596(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  404nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150603((S)-2-{(S)-3,3-Dimethyl-2-[(S)-3-methyl-2-(2-2H-te...)
Affinity DataKi:  808nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150592(2-{(S)-3,3-Dimethyl-2-[(S)-3-methyl-2-(2-2H-tetraz...)
Affinity DataKi:  3.11E+3nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  80nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  90nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  150nMAssay Description:At 48 hours prior to infection, Calu-3 2B4 cells were plated in a 96-well black-walled clear bottom plate at 5x104 cells/well. A 10 mM stock of NHC w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  300nMAssay Description:Vero E6 cells were plated at 20,000 cells/well in a 96-well plate. 24hr later, medium containing a dose response of NHC was added concurrent with SAR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed