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Found 63 with Last Name = 'kosa' and Initial = 'mb'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061306((3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061307(AG-1254 | CHEMBL128696 | N-[(1R,2R)-3-(2-tert-Buty...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061308((3S,4aS,8aS)-2-[(2R,3S)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061305((3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  98nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065732((E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-m...)
Affinity DataEC50:  4.00E+3nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075614((E)-(S)-4-{(2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-...)
Affinity DataEC50:  1nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075612((E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-m...)
Affinity DataEC50:  1.60E+3nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075615((E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-m...)
Affinity DataEC50:  30nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065693((E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-m...)
Affinity DataEC50:  5.60E+3nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11230(AG7088 analogue 2d | CHEMBL277716 | N-[(benzyloxy)...)
Affinity DataEC50:  30nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075611((E)-(S)-4-((S)-3-(4-Fluoro-phenyl)-2-{(S)-3-methyl...)
Affinity DataEC50:  20nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11229(AG7088 analogue 2a | CHEMBL20636 | N-[(5-methyliso...)
Affinity DataEC50:  10nMAssay Description:Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111464((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  6nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 1A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  44nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111460(4-[2-(3-Acetylamino-2-oxo-2H-pyridin-1-yl)-3-pheny...)
Affinity DataEC50:  888nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  85nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  10nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 23)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  33nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111464((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  5nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  109nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  36nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 16)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110351((E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2...)
Affinity DataEC50:  372nMAssay Description:antirhinoviral activity against Human Rhinovirus Protease 3C (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110351((E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2...)
Affinity DataEC50:  33nMAssay Description:antirhinoviral activity against Human Rhinovirus Protease 3C (serotype 14)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  3nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 14)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111463(6-Carbamoyl-4-{2-[3-(2,2-dimethyl-propionylamino)-...)
Affinity DataEC50:  518nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111461(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  3nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110353((E)-(S)-4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-py...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  12nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 78)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111466(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  3nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 14)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111457(6-Carbamoyl-4-(2-{3-[([1,3]dithiolane-2-carbonyl)-...)
Affinity DataEC50:  104nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111458(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  178nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50087765((METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLA...)
Affinity DataEC50:  440nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111462(6-Carbamoyl-4-{2-[3-(cyclopentanecarbonyl-amino)-2...)
Affinity DataEC50:  34nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  48nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111456(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  14nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111459(6-Carbamoyl-4-(2-{2-oxo-3-[(tetrahydro-furan-2-car...)
Affinity DataEC50:  1.78E+3nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111454(4-(3-(4-Fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3...)
Affinity DataEC50:  2nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065606((E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-m...)
Affinity DataEC50:  540nMAssay Description:antirhinoviral activity against Human Rhinovirus Protease 3C (serotype 14)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111461(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  513nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 1A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111456(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  111nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111457(6-Carbamoyl-4-(2-{3-[([1,3]dithiolane-2-carbonyl)-...)
Affinity DataEC50:  1.18E+3nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 1A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  9nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 19)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  3nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype Hanks)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111455((1S,5S)-4-((S)-3-(3,4-Difluoro-phenyl)-2-{3-[(5-me...)
Affinity DataEC50:  100nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 25)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111461(4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-...)
Affinity DataEC50:  32nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111457(6-Carbamoyl-4-(2-{3-[([1,3]dithiolane-2-carbonyl)-...)
Affinity DataEC50:  1.41E+3nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111469(3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propox...)
Affinity DataEC50:  58nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111454(4-(3-(4-Fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3...)
Affinity DataEC50:  4nMAssay Description:antirhinoviral activity against HRV Protease 3CP (serotype 10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111465(6-Carbamoyl-4-(2-{3-[(5-chloro-isoxazole-3-carbony...)
Affinity DataEC50:  24nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111468(6-Carbamoyl-4-(2-{3-[(5-methyl-isoxazole-3-carbony...)
Affinity DataEC50:  16nMAssay Description:Inhibition of HRV Protease 3CP (serotype 14).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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