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Found 8543 with Last Name = 'laird' and Initial = 'e'
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203205((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203200((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203199((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203211((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203210((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  15.8nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203197((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203206((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203208((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203202((R)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(naphthal...)
Affinity DataKi:  132nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203203((S)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  143nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203207(3-(RS)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(napht...)
Affinity DataKi:  382nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203204((S)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203198((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.33E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203208((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203210((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203197((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203199((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  3.50E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203211((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  4.92E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203200((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203207(3-(RS)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(napht...)
Affinity DataKi:  5.60E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203205((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  5.70E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203198((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  2.41E+5nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25619((1Z)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]...)
Affinity DataIC50:  0.0200nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25636((1Z)-5-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyr...)
Affinity DataIC50:  0.0300nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25625((1S,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50:  0.0400nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224846(4-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25629(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.0500nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224838(1-{6-[4-(6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25626((1R,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50:  0.0900nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224842(1-(6-{4-[4-(3-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224852(1-{6-[4-(6-chloro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224847(3-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224856(1-{6-[4-(1H-benzoimidazol-2-yl)-phenoxy]-pyridin-3...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224837(1-(6-{4-[4-(4-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.130nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25618((1Z)-5-[3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihy...)
Affinity DataIC50:  0.150nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224857(1-(6-{4-[4-(2-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50496954(CHEMBL3236470)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50496941(CHEMBL3236463)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50496943(CHEMBL3236471)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50484212(CHEMBL1822264)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full length B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25638((1Z)-5-[1-(oxan-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  0.220nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25641(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.230nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50496948(CHEMBL3236472)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50496946(CHEMBL3236464)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25624((1R,2R)-2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50:  0.330nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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