TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair