Compile Data Set for Download or QSAR
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Found 59 with Last Name = 'leese' and Initial = 'mp'
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  8nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171448((9BETA,14BETA,17BETA)-17-HYDROXY-2-METHOXYESTRA-1,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of steroid sulfatase-mediated coversion of [3H]E1S to E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200937(CHEMBL219321 | estradiol 3-O-sulfamate)
Affinity DataIC50:  16nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50159804(CHEMBL221802 | estradiol 3,17-O,O-bis-sulfamate | ...)
Affinity DataIC50:  18nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM11637((15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataIC50:  20nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50134329(CHEMBL122708 | Sulfamic acid (11R,12S,15S,16S)-13-...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  25nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataIC50:  25nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171448((9BETA,14BETA,17BETA)-17-HYDROXY-2-METHOXYESTRA-1,...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13424((15S)-14-hydroxy-4-methoxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  34nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200936((9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,...)
Affinity DataIC50:  39nMAssay Description:Inhibition of steroid sulfatase-mediated coversion of [3H]E1S to E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13426((15S)-4-methoxy-15-methyl-5-(sulfamoyloxy)tetracyc...)
Affinity DataIC50:  39nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200936((9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,...)
Affinity DataIC50:  39nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50219531(17beta-carbamoyloxy-3-sulfamoyloxyestra-1,3,5(10)-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM11637((15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataIC50:  42nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171450((8R,9S,13S,14S)-2-Methoxy-13-methyl-17-oxo-7,8,9,1...)
Affinity DataIC50:  42nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50134329(CHEMBL122708 | Sulfamic acid (11R,12S,15S,16S)-13-...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13423(CHEMBL167368 | STX 118 | [3-(2-cyclohexylethyl)-4-...)
Affinity DataIC50:  46nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13423(CHEMBL167368 | STX 118 | [3-(2-cyclohexylethyl)-4-...)
Affinity DataIC50:  59nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13419((15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataIC50:  92nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171445((8R,9S,13S,14S)-13-Methyl-2-methylsulfanyl-17-oxo-...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50372895(CHEMBL408967)
Affinity DataIC50:  130nMAssay Description:Inhibition of steroid sulfatase-mediated coversion of [3H]E1S to E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200942(3-O-sulfamoylestradiol 17beta-O-(N,N-dipentyl)sulf...)
Affinity DataIC50:  190nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13428((15S)-4-ethyl-15-methyl-5-(sulfamoyloxy)tetracyclo...)
Affinity DataIC50:  290nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200939(2-methylsulfanylestradiol 3,17-O,O-bis-sulfamate |...)
Affinity DataIC50:  320nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13427((15S)-4-ethyl-15-methyl-14-oxotetracyclo[8.7.0.0^{...)
Affinity DataIC50:  332nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171450((8R,9S,13S,14S)-2-Methoxy-13-methyl-17-oxo-7,8,9,1...)
Affinity DataIC50:  376nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13424((15S)-14-hydroxy-4-methoxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  376nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200936((9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,...)
Affinity DataIC50:  379nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13426((15S)-4-methoxy-15-methyl-5-(sulfamoyloxy)tetracyc...)
Affinity DataIC50:  379nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200936((9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,...)
Affinity DataIC50:  379nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50219532(17beta-Carbamoyloxy-2-methoxy-3-sulfamoyloxyestra-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13425((15S)-5-hydroxy-4-methoxy-15-methyltetracyclo[8.7....)
Affinity DataIC50:  526nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200940((13ALPHA,14BETA,17ALPHA)-3-HYDROXY-2-METHOXYESTRA-...)
Affinity DataIC50:  526nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200940((13ALPHA,14BETA,17ALPHA)-3-HYDROXY-2-METHOXYESTRA-...)
Affinity DataIC50:  526nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171446((8R,9S,13S,14S)-2-Ethoxy-13-methyl-17-oxo-7,8,9,11...)
Affinity DataIC50:  890nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171449((11R,12S,15S,16S,17S)-2-Ethyl-17-hydroxy-13-methyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200941((9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50372894(CHEMBL407952)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of steroid sulfatase-mediated coversion of [3H]E1S to E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50372895(CHEMBL408967)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50171447((8R,9S,13S,14S)-2-Ethyl-13-methyl-17-oxo-7,8,9,11,...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against steroid sulfatase in placental microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13428((15S)-4-ethyl-15-methyl-5-(sulfamoyloxy)tetracyclo...)
Affinity DataIC50:  1.90E+3nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM50200938(CHEMBL220493 | estradiol 17-O-sulfamate)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of STS in placental microsomes by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13422(667-COUMATE deriv. 7 | 9-oxo-8-oxatricyclo[8.5.0.0...)
Affinity DataIC50: >1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13421(methyl({[(15S)-15-methyl-14-oxotetracyclo[8.7.0.0^...)
Affinity DataIC50: >1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13420(amino-N-[(15S)-15-methyl-14-oxotetracyclo[8.7.0.0^...)
Affinity DataIC50: >1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13425((15S)-5-hydroxy-4-methoxy-15-methyltetracyclo[8.7....)
Affinity DataIC50: >1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13427((15S)-4-ethyl-15-methyl-14-oxotetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13429((2R,5S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0...)
Affinity DataIC50: >1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13430([(2R,5S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0....)
Affinity DataIC50: >1.00E+4nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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