TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
SchröDinger
US Patent
Affinity DataIC50: 0.900nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 1.21nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 1.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 1.74nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 2.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 2.44nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 3nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 3.41nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 3.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 3.61nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 3.70nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 3.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 4nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 4.30nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 4.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 4.5nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 4.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 4.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 4.70nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 4.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 4.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 4.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 5.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 5.44nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 5.70nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 6nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 6.10nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 6.30nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 7.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 7.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 7.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 7.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 7.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
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US Patent
Affinity DataIC50: 8.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 8.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
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US Patent
Affinity DataIC50: 8.5nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 9nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
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US Patent
SchröDinger
US Patent
Affinity DataIC50: 9.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger
US Patent
SchröDinger
US Patent
Affinity DataIC50: 9.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair