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Found 4848 with Last Name = 'leffler' and Initial = 'a'
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631495(US20230348424, Example 78)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631686(US20230348424, Example 269)
Affinity DataIC50:  1.21nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631683(1-((S)-1-acetyl-3-methylpyrrolidin-3-yl)-N-((R)-1-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631687(US20230348424, Example 270)
Affinity DataIC50:  1.74nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369033(CHEMBL4167096)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631681(US20230348424, Example 264)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631684(US20230348424, Example 267)
Affinity DataIC50:  2.44nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631543(US20230348424, Example 126 | US20230348424, Exampl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50368995(CHEMBL4159819)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM493606(US10988445, Example 202)
Affinity DataIC50:  3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631615(US20230348424, Example 198)
Affinity DataIC50:  3.41nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631526(US20230348424, Example 109 | US20230348424, Exampl...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631621(US20230348424, Example 204)
Affinity DataIC50:  3.61nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631496(: N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethy...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631559(US20230348424, Example 142 | US20230348424, Exampl...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631561(US20230348424, Example 144 | US20230348424, Exampl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631627(US20230348424, Example 210)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631543(US20230348424, Example 126 | US20230348424, Exampl...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631464(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631620(US20230348424, Example 203)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631490(1-((1R,2S)-[1,1′-bi(cyclopropan)]-2-yl)-N-((...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631702(US20230348424, Example 285)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631649(US20230348424, Example 232 | US20230348424, Exampl...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631724(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631559(US20230348424, Example 142 | US20230348424, Exampl...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631563(US20230348424, Example 146 | US20230348424, Exampl...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631612(US20230348424, Example 195)
Affinity DataIC50:  5.44nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631520(US20230348424, Example 103 | US20230348424, Exampl...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)
Affinity DataIC50:  6nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631553(US20230348424, Example 136 | US20230348424, Exampl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369079(CHEMBL4176887)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631600(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631660(US20230348424, Example 243 | US20230348424, Exampl...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50368990(CHEMBL4163215)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50368993(CHEMBL4163193)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369036(CHEMBL4173908)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631634((R)-1- (bicyclo[1.1.1]pentan-1- yl)-N-(1-(3- (difl...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631561(US20230348424, Example 144 | US20230348424, Exampl...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631568(US20230348424, Example 151 | US20230348424, Exampl...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631458(: (R)-N-(1-(3-(difluoromethyl)-2-fluorophenyl)ethy...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631709(US20230348424, Example 292)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631545(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631524(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631534(US20230348424, Example 117 | US20230348424, Exampl...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50445877(CHEMBL3105681)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631551(US20230348424, Example 134 | US20230348424, Exampl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631707(: 1-((1S,5S)-3-oxabicyclo[3.1.0]hexan-1-yl)-N-((R)...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631651(US20230348424, Example 234 | US20230348424, Exampl...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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