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Found 225 with Last Name = 'levin' and Initial = 'rb'
TargetDimer of Gag-Pol polyprotein [489-587,V571I](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.0520nM ΔG°:  -59.7kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  0.0620nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0620nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,L565M](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.114nM ΔG°:  -57.7kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366785(NELFINAVIR)
Affinity DataKi:  0.140nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.240nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,I539L](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.323nM ΔG°:  -55.1kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.358nM ΔG°:  -54.8kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,L512I](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.585nM ΔG°:  -53.6kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,V521I](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  2.64nM ΔG°:  -49.8kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,L512V](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  2.81nM ΔG°:  -49.6kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,I573V](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  3.11nM ΔG°:  -49.4kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  3.32nM ΔG°:  -49.2kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  3.70nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (K-60)More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,I536L](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  6.62nM ΔG°:  -47.5kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  15nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (A-44)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  15nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (A-44)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366785(NELFINAVIR)
Affinity DataKi:  16nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (A-44)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  23nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (V-18)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366785(NELFINAVIR)
Affinity DataKi:  27nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (V-18)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366785(NELFINAVIR)
Affinity DataKi:  33nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (K-60)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  40nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (K-60)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  40nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (V-18)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  50nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (K-60)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  60nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (A-44)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135430(CHEMBL434033 | Naphthalene-2-carboxylic acid (3R,5...)
Affinity DataKi:  110nMAssay Description:Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  117nMAssay Description:Dissociation constant obtained by inhibition of mutant HIV-protease (V-18)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141198(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.15)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141194(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.03)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141210(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.15)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141206(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141199(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid 5-[(...)
Affinity DataKi:  200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.18)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141196(1-[3-methyl-2-[2-methyl-1-(2-pyrazinylcarboxamido)...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.18)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141203(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  210nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141202(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <220nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.15)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141186(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  290nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135432(CHEMBL340890 | Naphthalene-2-carboxylic acid (3R,5...)
Affinity DataKi:  400nMAssay Description:Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141207(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  430nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141193(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  520nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141212(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  540nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141188(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  800nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135437(3,4-Dihydro-2H-quinoline-1-carboxylic acid (3R,5S)...)
Affinity DataKi:  890nMAssay Description:Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135442((S)-4-Acetylamino-4-[(S)-1-((S)-1-{(S)-1-[(2S,4R)-...)
Affinity DataKi:  890nMAssay Description:Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141217(1,2,3,4-Tetrahydro-naphthalene-2-carboxylic acid (...)
Affinity DataKi:  890nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141219(CHEMBL407433 | Pyrazine-2-carboxylic acid [(R)-1-(...)
Affinity DataKi:  920nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141209(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  970nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141190(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  1.12E+3nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141191(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141197(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  1.63E+3nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135429(CHEMBL335769 | Pyrazine-2-carboxylic acid ((R)-1-{...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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