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Found 329 with Last Name = 'liu' and Initial = 'xj'
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213665((S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)pr...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213671((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(quinoxalin-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213664((S)-5-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162026(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213659((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-y...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213658((S)-1-(3-(1-(2-(1H-benzo[d][1,2,3]triazol-5-yl)eth...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213652((S)-1-(3-(1-(2-(3H-[1,2,3]triazolo[4,5-b]pyridin-6...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213663(1-(3-((S)-1-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)e...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162008((R)-1-(2-chloro-6-fluorobenzyl)-3-(2-amino-2-pheny...)
Affinity DataKi:  0.610nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213657((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(6-fluoro-1H...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213662((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(2-methyl-1H...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  1nMAssay Description:The compound was tested for binding affinity against Insulin-like growth factor binding protein 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149263(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213653((S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152188((4-Chloro-benzyl)-[3-(6-dimethylamino-4-methyl-pyr...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213669((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-y...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213650(CHEMBL233341 | adamantan-1-yl-{2-(3,5-dimethyl-phe...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50071235(CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213666((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-y...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213670((S)-7-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162003(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213656((S)-4-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor-binding protein 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50106431(1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoli...)
Affinity DataKi:  2.10nMAssay Description:The compound was tested for binding affinity against insulin-like growth factor binding protein 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152164(CHEMBL366155 | [3-(6-Dimethylamino-2-methyl-pyridi...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50161500((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152183(CHEMBL186033 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152178(CHEMBL361509 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152179(CHEMBL185705 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152176((3,4-Dichloro-benzyl)-[3-(6-dimethylamino-4-methyl...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152173(Butyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213667((S)-2-(2-chlorophenyl)-1-(2-(3,5-dimethylphenyl)-3...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152169(CHEMBL189821 | Cyclopropylmethyl-[3-(6-dimethylami...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162005(3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-chloro-phenyl)...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152170(Benzyl-butyl-[3-(6-dimethylamino-4-methyl-pyridin-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162014(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162023(3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152160(CHEMBL186592 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162006(3-((R)-2-Amino-2-phenyl-ethyl)-5-benzo[1,3]dioxol-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50148889(CHEMBL121896 | [3-(2,4-Dimethoxy-phenyl)-2,5-dimet...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity for Monkey gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50116105(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162024(3-((S)-2-Cyclobutylamino-propyl)-1-(2,6-difluoro-b...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162017(3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152185(CHEMBL360851 | Dibutyl-[3-(6-dimethylamino-4-methy...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152162(CHEMBL188844 | CHEMBL2165204 | [3-(6-Dimethylamino...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213673((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-y...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162030(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-bromo-benzyl)-...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213655((S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(tetrahydro-...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152186(CHEMBL188609 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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