Affinity DataKi: 3nMAssay Description:Compound was evaluated for its binding affinity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3 protease.More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataKi: 1.40E+4nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of human liver Cathepsin BMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 108nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 435nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 635nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3 protease.More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibition of human leukocyte elastase after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
TargetRibonucleoside-diphosphate reductase large subunit(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Bio-MéGa/Boehringer Ingelheim Research
Curated by ChEMBL
Affinity DataIC50: 880nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3 protease.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3 protease.More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human CatB after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of rat hapatic, acyl coA cholesterol acetyltransferaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against NS3-4A pep proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibitory concentration required against NS3 Protease of Hepatitis C VirusMore data for this Ligand-Target Pair