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Found 171 with Last Name = 'lobeck' and Initial = 'wg'
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor measured using radioligand ([3H]spiperone) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367315(CHEMBL1203220)
Affinity DataIC50:  0.900nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019378(3-[4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-buty...)
Affinity DataIC50:  1nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  1.40nMAssay Description:Compound was tested in vitro for its ability to displace radioligand (+)-[3H]-3-PPP from rat cortical sigma receptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019359(4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-1-(4-...)
Affinity DataIC50:  2nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019376(4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(4-fl...)
Affinity DataIC50:  2nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019359(4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-1-(4-...)
Affinity DataIC50:  2nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019372(8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-pr...)
Affinity DataIC50:  3nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019368(1-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  4nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019377(8-{4-[4-(6-Chloro-benzo[d]isoxazol-3-yl)-piperazin...)
Affinity DataIC50:  5nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019375(4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(4-fl...)
Affinity DataIC50:  5nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002334(1-(4-Fluoro-phenyl)-4-(4-pyrimidin-2-yl-piperazin-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]WB-4101 binding to rat cortical Alpha-1 adrenergic receptor in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibitory concentration against radioligand [3H]spiperone binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  7nMAssay Description:Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019358(8-[4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-buty...)
Affinity DataIC50:  7nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019379(4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-1-(4-...)
Affinity DataIC50:  8nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  8nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367314(CHEMBL1203224)
Affinity DataIC50:  9nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367316(CHEMBL1203226)
Affinity DataIC50:  9nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019379(4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-1-(4-...)
Affinity DataIC50:  10nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  13nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was measured using radioligand ([3H]5-HT) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM79181(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Affinity DataIC50:  16nMAssay Description:Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataIC50:  18nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor was measured using radioligand ([3H]spiperone) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  21nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor measured using radioligand ([3H]spiperone) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002329(1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [3H]WB-4101 binding to rat cortical Alpha-1 adrenergic receptor in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002330(4-[4-(5-Chloro-pyrimidin-2-yl)-piperazin-1-yl]-1-(...)
Affinity DataIC50:  22nMAssay Description:Displacement of (+)-[3H]-3-PPP from rat cortical sigma siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019368(1-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  23nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002331(4-[4-(5-Fluoro-4-methoxy-pyrimidin-2-yl)-piperazin...)
Affinity DataIC50:  24nMAssay Description:Displacement of (+)-[3H]-3-PPP from rat cortical sigma siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019358(8-[4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-buty...)
Affinity DataIC50:  25nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002322(4-[4-(5-Fluoro-4-methylsulfanyl-pyrimidin-2-yl)-pi...)
Affinity DataIC50:  26nMAssay Description:Displacement of (+)-[3H]-3-PPP from rat cortical sigma siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002323(4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4...)
Affinity DataIC50:  26nMAssay Description:Displacement of (+)-[3H]-3-PPP from rat cortical sigma siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50036737((R)-1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2...)
Affinity DataIC50:  28nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to haloperidol-sensitive sigma binding site in whole guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002339(1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)...)
Affinity DataIC50:  29nMAssay Description:Inhibition of [3H]WB-4101 binding to rat cortical Alpha-1 adrenergic receptor in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019376(4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(4-fl...)
Affinity DataIC50:  30nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  31nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50036737((R)-1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2...)
Affinity DataIC50:  32nMAssay Description:Inhibitory concentration against radioligand [3H]DTG binding to haloperidol-sensitive sigma binding site in whole guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019362(3-{4-[4-(5-Chloro-benzo[d]isoxazol-3-yl)-piperazin...)
Affinity DataIC50:  33nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019365(8-{4-[4-(1,3-Dihydro-benzo[c]isothiazol-3-yl)-pipe...)
Affinity DataIC50:  33nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  40nMAssay Description:Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367316(CHEMBL1203226)
Affinity DataIC50:  42nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50036737((R)-1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration against radioligand [3H](+)-NAN binding to haloperidol-sensitive sigma binding site in whole guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019366(8-{4-[4-(5-Chloro-benzo[d]isoxazol-3-yl)-piperazin...)
Affinity DataIC50:  46nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  47nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367319(CHEMBL1203225)
Affinity DataIC50:  49nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002335(4-[4-(5-Chloro-pyrimidin-2-yl)-piperazin-1-yl]-1-(...)
Affinity DataIC50:  51nMAssay Description:Inhibition of [3H]WB-4101 binding to rat cortical Alpha-1 adrenergic receptor in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367315(CHEMBL1203220)
Affinity DataIC50:  53nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367314(CHEMBL1203224)
Affinity DataIC50:  55nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002335(4-[4-(5-Chloro-pyrimidin-2-yl)-piperazin-1-yl]-1-(...)
Affinity DataIC50:  57nMAssay Description:Displacement of (+)-[3H]-3-PPP from rat cortical sigma siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019377(8-{4-[4-(6-Chloro-benzo[d]isoxazol-3-yl)-piperazin...)
Affinity DataIC50:  59nMAssay Description:In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory against radioligand [3H]spiperone binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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