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Found 64 with Last Name = 'loeffler' and Initial = 'bm'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11113(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Affinity DataKi:  11nM IC50:  15nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50:  0.100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11589(1c-para-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50:  0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11588(1c-meta-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50:  0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309502(CHEMBL591279 | rac-3-(3-(fluoromethyl)phenyl)-9,10...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11580(1c-meta-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50:  0.900nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309504(CHEMBL598470 | rac-3-(4-(fluoromethyl)pyridin-2-yl...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309503(CHEMBL601937 | rac-3-(2,5-dimethylphenyl)-9,10-dim...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309469((R)-1-((2S,3S,11bS)-2-amino-9,10-dimethoxy-2,3,4,6...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11592(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,4-difl...)
Affinity DataIC50:  3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309471((R)-1-((2S,3S,11bS)-2-amino-9,10-dimethoxy-2,3,4,6...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309463((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309470((4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309464((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11578(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyr...)
Affinity DataIC50:  10nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309497((2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-y...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309468((S)-1-((2S,3S,11bS)-2-amino-9,10-dimethoxy-2,3,4,6...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309465((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309497((2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-y...)
Affinity DataIC50:  19nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309462((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309455(1-((2S,3S,11bS)-2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309454((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309500(CHEMBL591277 | rac-3-(3-cyclopropylphenyl)-9,10-di...)
Affinity DataIC50:  38nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11587(1c-ortho-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50:  47nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11583(1c-para-Cl | 5-(aminomethyl)-2-(4-chlorophenyl)-6-...)
Affinity DataIC50:  53nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309499(CHEMBL591982 | rac-3-(3-ethylphenyl)-9,10-dimethox...)
Affinity DataIC50:  61nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11581(1c-para-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50:  90nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11586(1c-para-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11590(1c-meta-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  130nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309459((SR, SR, SR)-9,10-Dimethoxy-3-(1-oxo-1lambda*4*-[1...)
Affinity DataIC50:  142nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309461((SR, SR, SR)-3-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  142nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11591(1c-para-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  180nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11582(1c-meta-Cl | 5-(aminomethyl)-2-(3-chlorophenyl)-6-...)
Affinity DataIC50:  240nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11585(1c-meta-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  340nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11584(1c-ortho-OMe | 5-(aminomethyl)-6-(2,4-dichlorophen...)
Affinity DataIC50:  350nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309457((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309453((SR, SR, SR)1-(2-amino-9,10-dimethoxy-2,3,4,6,7,11...)
Affinity DataIC50:  510nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11565(1b-para-Me | 5-(aminomethyl)-6-(4-methylphenyl)-2-...)
Affinity DataIC50:  1.00E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11577(1b-para-CF3 | 5-(aminomethyl)-2-phenyl-6-[4-(trifl...)
Affinity DataIC50:  1.10E+3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309460((SR, SR, SR)-3-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309458((SR, SR, SR)-9,10-Dimethoxy-3-(1-oxo-1lambda*4*-is...)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11568(1b-para-Cl | 5-(aminomethyl)-6-(4-chlorophenyl)-2-...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11569(1b-ortho-OMe | 5-(aminomethyl)-6-(2-methoxyphenyl)...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11563(1b-ortho-Me | 5-(aminomethyl)-6-(2-methylphenyl)-2...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11579(1c-ortho-Me | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  1.75E+3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309467((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11566(1b-ortho-Cl | 5-(aminomethyl)-6-(2-chlorophenyl)-2...)
Affinity DataIC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309501(CHEMBL591278 | rac-3-(3-isopropylphenyl)-9,10-dime...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309456(1-((2R,3R,11bR)-2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM50309466((SR, SR, SR)-1-(2-amino-9,10-dimethoxy-2,3,4,6,7,1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human DPP4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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