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Found 117 with Last Name = 'lucas' and Initial = 'r'
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056769((S)-1-(3,3-Diphenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.00250nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454822(CHEMBL2062141 | L-370518)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056773((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070824(CHEMBL47920 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  0.120nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056774((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067796(CHEMBL11157 | L-374087 | N-((6-amino-2-methylpyrid...)
Affinity DataKi:  0.5nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060760((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.820nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070823(CHEMBL45480 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  0.850nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060746(((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylm...)
Affinity DataKi:  2.20nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070827(CHEMBL46135 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  2.60nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060739((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  3nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056770((S)-1-((R)-2-Methanesulfonylamino-3-phenyl-propion...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060741(((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  3nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060755(((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylm...)
Affinity DataKi:  3.60nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060752((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  3.90nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056769((S)-1-(3,3-Diphenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070825(CHEMBL49457 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  4nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366827(CHEMBL125181 | L-371912)
Affinity DataKi:  5nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056771((2S)-N-[(4-aminocyclohexyl)methyl]-1-[(2R)-2-(meth...)
Affinity DataKi:  5nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060759(((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  7.60nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060745((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  9nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060748((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  10nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060747((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  11nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070826(CHEMBL46331 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060751((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  12nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070828(CHEMBL431535 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  16nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50069192(CHEMBL48929 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  26nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060740((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  70nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060754((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  110nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060744((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  130nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060749((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  350nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060742(((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbam...)
Affinity DataKi:  350nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060761((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  360nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060757((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  380nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060739((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  430nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056769((S)-1-(3,3-Diphenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  490nMAssay Description:Binding affinity towards PlasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060750((S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethane...)
Affinity DataKi:  510nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060756(((R)-2-{(S)-2-[(5-Amino-thiophen-3-ylmethyl)-carba...)
Affinity DataKi:  560nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060741(((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  657nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060753(((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbam...)
Affinity DataKi:  900nMAssay Description:In vitro inhibitory activity against human thrombin(IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060760((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  1.20E+3nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060759(((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbam...)
Affinity DataKi:  1.30E+3nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070823(CHEMBL45480 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  1.40E+3nMAssay Description:Compound was evaluated to inhibit the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060746(((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylm...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070828(CHEMBL431535 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  1.70E+3nMAssay Description:Compound was evaluated to inhibit the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070825(CHEMBL49457 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  1.90E+3nMAssay Description:Compound was evaluated to inhibit the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060755(((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylm...)
Affinity DataKi:  2.50E+3nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070826(CHEMBL46331 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  2.50E+3nMAssay Description:Compound was evaluated to inhibit the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070824(CHEMBL47920 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  2.60E+3nMAssay Description:Compound was evaluated to inhibit the trypsin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060752((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  3.00E+3nMAssay Description:In vitro inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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