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Found 396 with Last Name = 'lundell' and Initial = 'dj'
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  0.0600nM ΔG°:  -57.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325003((R)-5-(4-(5-chloro-6-oxo-1,6-dihydropyridin-3-yl)p...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26524((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...)
Affinity DataKi:  0.140nM ΔG°:  -55.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26525((1S,2R)-1-N-hydroxy-2-({4-[(2-phenylquinolin-4-yl)...)
Affinity DataKi:  0.180nM ΔG°:  -55.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325002((R)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343977((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-4-oxo-N-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329148(1,1,1-trifluoro-N-((1-(1-(2-fluorophenylsulfonyl)-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50305990(CHEMBL596388 | N-((1-(4-chloro-2-(2-fluorophenylsu...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329147(1,1,1-trifluoro-N-((1-(1-(2-fluorophenylsulfonyl)-...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329151(1,1,1-trifluoro-N-((1-(1-(2-fluorophenylsulfonyl)-...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM85739(CHEMBL178372 | JTE-907 | N-(1,3-Benzodioxole-5-ylm...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for cannabinoid receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50305989(CHEMBL596387 | N-((1-(4-chloro-2-(2-fluorophenylsu...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329130((S)-1,1,1-trifluoro-N-(6-(1-(pyridin-2-ylsulfonyl)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329129(CHEMBL1271093 | N-((4-ethyl-1-(5-fluoro-1-(2-fluor...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342973((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342953((2R,3R)-2,3-dihydroxy-4-{(2R)-2-[2-(methylamino)-5...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329150(1,1,1-trifluoro-N-(1-(1-(1-(2-fluorophenylsulfonyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329144(1,1,1-trifluoro-N-(((3S,4R)-1-(1-(2-fluorophenylsu...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342962((2R,3R)-4-((R)-2-amino-5-(2-(ethylamino)thiazol-4-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343976((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-N-((5-((...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342972((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325010((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325008((R)-5-(4-(3,5-dimethylisoxazol-4-yl)phenyl)-5-((6-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50324998((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325005((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342957((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325000((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306002(CHEMBL595705 | N-(6-(5-chloro-2-(4-methoxyphenylsu...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211605((S)-N-(1-(4-(4-chloro-2-(2-fluorophenylsulfonyl)ph...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329159((R)-N-(1-(4-(4-chloro-2-(2-fluorophenylsulfonyl)ph...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50324999((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.770nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325014((R)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329137(1,1,1-trifluoro-N-((1-(1-(2-fluorophenylsulfonyl)-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313841((R)-5-(4-fluorophenyl)-5-((6-methoxy-1-oxoisoindol...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342963((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342963((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325009((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306008(1,1,1-trifluoro-N-(6-(2-(pyridin-2-ylsulfonyl)-5-(...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342966(CHEMBL1770638 | rac-(2R,3R)-N-((R)-1-(4-(1H-pyrazo...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325004((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329133(1,1,1-trifluoro-N-((1-(1-(pyridin-2-ylsulfonyl)-1H...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342959((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329139((S)-1,1,1-trifluoro-N-(6-(1-(2-fluorophenylsulfony...)
Affinity DataKi:  1nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342958((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342951((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342947((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325007((R)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  1nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325006((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325001((R)-5-(4-(2-aminopyridin-4-yl)phenyl)-5-((6-methox...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329135(1,1,1-trifluoro-N-((1-(2-(2-fluorophenylsulfonyl)f...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of beta-arrestin binding to recombinant cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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