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Found 4633 with Last Name = 'lv' and Initial = 'b'
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00100nMAssay Description:Inhibition of recombinant Escherichia coli DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in NADPH oxidation using dihydrofolate as substrate by fluorescence spectrophotometric ana...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50029090(CHEMBL3343301)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50029090(CHEMBL3343301)
Affinity DataKi:  0.0960nMAssay Description:Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50029091(CHEMBL3343299)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50029095(CHEMBL3343300)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50568077(CHEMBL4865195)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to Trypanosoma brucei rhodesainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50029091(CHEMBL3343299)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50029090(CHEMBL3343301)
Affinity DataKi:  0.870nMAssay Description:Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  0.910nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50190621(CHEMBL3827532 | US10870625, Compound 15)
Affinity DataKi:  0.980nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50514105(CHEMBL4441731)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]NAMH from mouse H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  1nMAssay Description:Inhibition of Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Homo sapiens (Human))
Max Planck Research Unit For Enzymology Of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50184825(Ac-Lys(N-epsilon-biotinoyl)-Ala-Ala-Bth-D-Thr(PO3H...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human Pin1 PPIase Activity by protease free PPIase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210931(UCP1175)
Affinity DataKi:  1.60nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50061231(2-Amino-5-(N'-propyl-guanidino)-pentanoic acid | C...)
Affinity DataKi:  1.80nMAssay Description:Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210929(UCP1172)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50190622(CHEMBL3827326)
Affinity DataKi:  1.90nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50118337(1-(benzo[b]thiophen-3-yl)-3-(4-(3,4-dihydro-2H-ben...)
Affinity DataKi:  1.91nMAssay Description:Antagonist activity at 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrnithine aminotransferase, mitochondrial(Homo sapiens (Human))
Hebrew University-Hadassah Medical Center

Curated by ChEMBL
LigandPNGBDBM50121376(GABACULINE)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human recombinant OAT using 1 mM alpha-ketoglutarate as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50190619(CHEMBL3827086 | US10870625, Compound 14)
Affinity DataKi:  2.10nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210929(UCP1172)
Affinity DataKi:  2.10nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50415830(CHEMBL1095256)
Affinity DataKi:  2.51nMAssay Description:Antagonist activity at 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50118336(1-(5-Fluoro-benzo[b]thiophen-3-yl)-3-(4-quinolin-8...)
Affinity DataKi:  2.69nMAssay Description:Antagonist activity at 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50118327(3-(4-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pi...)
Affinity DataKi:  3.02nMAssay Description:Antagonist activity at 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210928(UCP1164)
Affinity DataKi:  3.10nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50514105(CHEMBL4441731)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]NAMH from human H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
TargetOrnithine aminotransferase, mitochondrial(Homo sapiens (Human))
Hebrew University-Hadassah Medical Center

Curated by ChEMBL
LigandPNGBDBM50199989((1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluorometh...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human recombinant OAT using 1 mM alpha-ketoglutarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50190621(CHEMBL3827532 | US10870625, Compound 15)
Affinity DataKi:  4.80nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Homo sapiens (Human))
Max Planck Research Unit For Enzymology Of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50184823(Ac-Lys(N-epsilon-biotinoyl)-Ala-Ala-Bip-Thr(PO3H2)...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of human Pin1 PPIase Activity by protease free PPIase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50448835(CHEMBL3128246)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant rat nNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as nitric oxide formation measured for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM202643(US9242957, 7)
Affinity DataKi:  5nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM202644(US9242957, 8)
Affinity DataKi:  5nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50448825(CHEMBL3128245)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant rat nNOS overexpressed in Escherichia coli using L-arginine as substrate assessed as nitric oxide formation measured for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  5nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50102331(1-(2,5-Dimethyl-thiophen-3-yl)-3-[4-(2-methoxy-phe...)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of nNOSMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50190622(CHEMBL3827326)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM210931(UCP1175)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50190620(CHEMBL3828724)
Affinity DataKi:  5.70nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50442068(CHEMBL2441057)
Affinity DataKi:  6nMAssay Description:Inhibition of bovine thrombin using D-Phe-Pip-Arg-p-NA as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Consiglio Nazionale Delle Ricerche

Curated by ChEMBL
LigandPNGBDBM50442068(CHEMBL2441057)
Affinity DataKi:  6nMAssay Description:Inhibition of bovine thrombin using D-Phe-Pip-Arg-p-NA as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
In DepthDetails
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50118335(3-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazi...)
Affinity DataKi:  6.03nMAssay Description:Antagonist activity at 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50514097(CHEMBL4466700)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]NAMH from human H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50095181(CHEMBL96680 | N-(3-Aminomethyl-phenyl)-furan-2-car...)
Affinity DataKi:  6.30nMAssay Description:Inhibition against neuronal Nitric Oxide Synthase(nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Universidade Federal Da Para£Ba

Curated by ChEMBL
LigandPNGBDBM50102377(3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(thiophen-...)
Affinity DataKi:  6.46nMAssay Description:Antagonist activity at 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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