Affinity DataKi: 15nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: 153nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: 195nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Binding affinity to human mGlu2R expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 131nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 207nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 218nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 219nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Ortho-Biotech Oncology Research & Development
Curated by ChEMBL
Affinity DataIC50: 224nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Negative allosteric modulation at mGluR3 (unknown origin)More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 524nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 525nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Negative allosteric modulation at mGluR3 (unknown origin)More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair