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Found 771 with Last Name = 'mackie' and Initial = 'c'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50194617(CHEMBL3926416)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50392432(CHEMBL2151817)
Affinity DataKi:  153nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(CHEMBL1684242 | N-cyclobutyl-6-((3-fluorophenyl)et...)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM44464(2-(2-chloro-N-mesyl-anilino)-N-(3-chlorophenyl)ace...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50402788(CHEMBL2208408)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50402787(CHEMBL2208405)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50392425(CHEMBL2151790)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50:  15nMAssay Description:Binding affinity to human mGlu2R expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  66nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataIC50:  68nMAssay Description:Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  102nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064474(CHEMBL3401204)
Affinity DataIC50:  131nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064474(CHEMBL3401204)
Affinity DataIC50:  132nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  207nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064472(CHEMBL3401192)
Affinity DataIC50:  218nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064472(CHEMBL3401192)
Affinity DataIC50:  219nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50064444(CHEMBL3401195)
Affinity DataIC50:  290nMAssay Description:Negative allosteric modulation at mGluR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064475(CHEMBL3401205)
Affinity DataIC50:  524nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064475(CHEMBL3401205)
Affinity DataIC50:  525nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50064463(CHEMBL3401177)
Affinity DataIC50:  630nMAssay Description:Negative allosteric modulation at mGluR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064473(CHEMBL3401194)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50064473(CHEMBL3401194)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047394(CHEMBL3309848)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047406(CHEMBL3310738)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50402787(CHEMBL2208405)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50110188(CHEMBL3605277)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50110189(CHEMBL3605296)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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