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Found 529 with Last Name = 'maddaford' and Initial = 'sp'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206074((+/-)-N-{2-[2-(1-methyl-pyrrolidin-2-yl)-ethylamin...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401280(CHEMBL3216124)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206073(CHEMBL233652 | N-[2-(2-pyridin-2-yl-ethylamino)-be...)
Affinity DataIC50:  50nMAssay Description:Inhibition of rat neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50365335(CHEMBL1955937)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50379744(CHEMBL2011136)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401282(CHEMBL3216566)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357692(CHEMBL1915288)
Affinity DataIC50:  86nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206064(CHEMBL233857 | N-[2-(1-benzyl-piperidin-4-ylamino)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of rat neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357690(CHEMBL1915286)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394745(CHEMBL2165821)
Affinity DataIC50:  97nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  97nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357687(CHEMBL1956112)
Affinity DataIC50:  98nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206065(CHEMBL233655 | N-{2-[1-(3-methoxy-benzyl)-piperidi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50379740(CHEMBL2011132)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50365334(CHEMBL1955936)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401271(CHEMBL2203713 | CHEMBL3216328)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394739(CHEMBL2165827)
Affinity DataIC50:  115nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50379737(CHEMBL2011128)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50355311(CHEMBL1835114)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401279(CHEMBL3215893)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357688(CHEMBL1915284)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394744(CHEMBL2165822)
Affinity DataIC50:  133nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394741(CHEMBL2165825)
Affinity DataIC50:  139nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50379738(CHEMBL2011129)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357681(CHEMBL1915277)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384903(CHEMBL2036267)
Affinity DataIC50:  160nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401276(CHEMBL3215678)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394737(CHEMBL2165829)
Affinity DataIC50:  169nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394743(CHEMBL2165820)
Affinity DataIC50:  176nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50365336(CHEMBL1955938)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  190nMAssay Description:Inhibition of human nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50209508(CHEMBL242983 | N-(2-(4-(4-(3,4-dimethoxybenzyl)pip...)
Affinity DataIC50:  195nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401275(CHEMBL3216789)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401272(CHEMBL3142587)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50401272(CHEMBL3142587)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384902(CHEMBL2036276)
Affinity DataIC50:  200nMAssay Description:Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206080(CHEMBL233444 | N-{2-[1-(4-fluoro-benzyl)-piperidin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206070(CHEMBL412797 | N-[2-(2-morpholin-4-yl-ethylamino)-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206076(CHEMBL234498 | N-{2-[1-(4-methoxy-benzyl)-piperidi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50355309(CHEMBL1835013)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206067(CHEMBL233228 | N-(2-amino-benzothiazol-5-yl)-thiop...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50206082(CHEMBL397506 | N-(2-amino-benzothiazol-6-yl)-thiop...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357687(CHEMBL1956112)
Affinity DataIC50:  230nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394742(CHEMBL2165824)
Affinity DataIC50:  235nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394738(CHEMBL2165828)
Affinity DataIC50:  248nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357689(CHEMBL1915285)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50394740(CHEMBL2165826)
Affinity DataIC50:  267nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50357691(CHEMBL1915287)
Affinity DataIC50:  270nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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