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Found 261 with Last Name = 'maggiora' and Initial = 'l'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi: <1nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281641((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  4nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  5nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281651((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281640(CHEMBL433729 | Pyridine-2-carboxylic acid ((1S,2S,...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  9nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281648(CHEMBL166640 | [(S)-1-((1S,2S,4S)-1-Cyclohexylmeth...)
Affinity DataKi:  10nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281644(CHEMBL355867 | N*1*-[(1S,2S,4S)-1-Cyclohexylmethyl...)
Affinity DataKi:  14nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076372(1-[(S)-2-Oxo-1-pentafluorophenylmethyl-2-(4-pyridi...)
Affinity DataKi:  14nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281643((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi:  16nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076341((S)-N-Methyl-3-pentafluorophenyl-2-[3-(5-thioxo-4,...)
Affinity DataKi:  18nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  30nMAssay Description:Tested for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281652((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-{(...)
Affinity DataKi:  30nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281639((2S,4S,5S)-6-Cyclohexyl-5-hexanoylamino-4-hydroxy-...)
Affinity DataKi:  47nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  50nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281637((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-{(...)
Affinity DataKi:  61nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281646((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-(2...)
Affinity DataKi:  61nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  65nMAssay Description:Compound was evaluated for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281645((2S,4S,5S)-6-Cyclohexyl-5-(3,3-dimethyl-butyrylami...)
Affinity DataKi:  75nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  90nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076338((S)-3-(4-Fluoro-phenyl)-N-methyl-2-[3-(5-thioxo-4,...)
Affinity DataKi:  100nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  100nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  142nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  170nMAssay Description:Compound was evaluated for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  200nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  212nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  265nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076367(1-[(S)-1-(4-Fluoro-benzyl)-2-oxo-2-(4-pyridin-2-yl...)
Affinity DataKi:  270nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076357((S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thi...)
Affinity DataKi:  290nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  290nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  330nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076366((S)-N-Methyl-3-(4-nitro-phenyl)-2-[3-(5-thioxo-4,5...)
Affinity DataKi:  330nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076374(1-((S)-1-Benzyl-2-oxo-2-thiomorpholin-4-yl-ethyl)-...)
Affinity DataKi:  380nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076339((S)-3-(4-Hydroxy-phenyl)-N-methyl-2-[3-(5-thioxo-4...)
Affinity DataKi:  400nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076336(1-[(S)-1-Benzyl-2-oxo-2-(4-pyrimidin-2-yl-piperazi...)
Affinity DataKi:  420nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076351((S)-3-(4-Methoxy-phenyl)-N-methyl-2-[3-(5-thioxo-4...)
Affinity DataKi:  460nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076334((S)-N-(3,4-Dimethoxy-benzyl)-3-phenyl-2-[3-(5-thio...)
Affinity DataKi:  490nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50404974(5-NITRO-DUMP | CHEMBL2051758)
Affinity DataKi:  500nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027919(5-fluoro-deoxyuridinemonophosphate | CHEMBL416879)
Affinity DataKi:  500nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076382((S)-N-Benzyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[...)
Affinity DataKi:  510nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076342(1-[(S)-1-Benzyl-2-oxo-2-(4-pyridin-2-yl-piperazin-...)
Affinity DataKi:  520nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076346(1-((S)-1-Benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-3-(...)
Affinity DataKi:  660nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50241372((S)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-...)
Affinity DataKi:  710nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076372(1-[(S)-2-Oxo-1-pentafluorophenylmethyl-2-(4-pyridi...)
Affinity DataKi:  770nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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