Affinity DataKi: <1nMpH: 4.0Assay Description:Inhibition of human renin at pH 6.0More data for this Ligand-Target Pair
Affinity DataKi: <1nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0 (time-dependent inhibition, T1/2>30 s)More data for this Ligand-Target Pair
Affinity DataKi: 4nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 8nMpH: 7.4Assay Description:Inhibition of human renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataKi: 9nMpH: 7.4Assay Description:Inhibition of human renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataKi: 12nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 16nMpH: 7.4Assay Description:Inhibition of human renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataKi: 23nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 34nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 35nMpH: 4.0Assay Description:Inhibition of rabbit liver cathepsin D at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 67nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 99nMpH: 7.4Assay Description:Inhibition of human renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataKi: 150nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMpH: 7.4Assay Description:Inhibition of human renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nMpH: 7.4Assay Description:Inhibition of human renin at pH 7.4More data for this Ligand-Target Pair
Affinity DataKi: 3.50E+3nMpH: 4.0Assay Description:Inhibition of rabbit liver cathepsin D at pH 4.0More data for this Ligand-Target Pair
Affinity DataKi: 4.00E+4nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4More data for this Ligand-Target Pair
Affinity DataIC50: 0nMAssay Description:The LATS1 biochemical HTRF assay was performed using the HTRF KinEASE-STK S1 kit (CisBio, catalogue number 62ST1PEC) according to manufacturer's ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0670nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair