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Found 77 with Last Name = 'maréchal' and Initial = 'jd'
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataKi:  30nMAssay Description:Binding affinity for cytochrome P450 2D6More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  180nMAssay Description:Binding affinity for cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM87351(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
Affinity DataKi:  7.50E+3nMAssay Description:Binding affinity for cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataKi:  2.10E+4nMAssay Description:Binding affinity for cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataIC50:  8.40nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188069(12-oxo-10,12-dihydro-10-aza-4b-azonia-indeno[2,1-b...)
Affinity DataIC50:  410nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50066721(1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154453(1-(4-Fluoro-phenyl)-4-{4-[(4-fluoro-phenyl)-hydrox...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50370411(CINCHORINE | GNF-PF-3189)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154467(1-[3-(2,5-Dichloro-phenylsulfanyl)-propyl]-piperaz...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154454((3-Aminomethyl-7-chloro-quinolin-4-yl)-butyl-amine...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154460(3-(9-Methoxy-5,11-dimethyl-pyrido[4,3-b]carbazol-6...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154461(2-[1-(2-Chloro-benzyl)-2-methyl-5-methylsulfanyl-1...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154461(2-[1-(2-Chloro-benzyl)-2-methyl-5-methylsulfanyl-1...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188071(CHEMBL213805 | biphenyl-4-carboxylic acid [2-(1H-i...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154459(CHEMBL189830 | NCI-180973 | {2-[4-((E)-1,2-Dipheny...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50014779(1-[Bis-(4-chloro-phenyl)-methyl]-piperazine | CHEM...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154452(1-Amino-3-(4-chloro-benzylsulfanyl)-propan-2-ol | ...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154468(2-(2-Amino-ethyl)-3-(4-chloro-phenyl)-3-hydroxy-2,...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154469(CHEMBL188797 | Diethyl-{2-[2-(4-oxo-2-phenyl-4H-ch...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM87351(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM87351(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50022673((5-(3,4-dichlorophenyl)-2,3-dihydro-1H-pyrrolizine...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154462(CHEMBL188427 | N-Methyl-N-[4-(7-methyl-1H-imidazo[...)
Affinity DataIC50:  1.81E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154449(5-[4-(2-Amino-ethylamino)-3-nitro-phenyl]-6-ethyl-...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188075(CHEMBL378617 | N-(2-(1H-indol-3-yl)ethyl)-4-bromo-...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188066(CHEMBL213302 | N-(2-(1H-indol-3-yl)ethyl)-4-chloro...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50033894(5-Amino-2-(2-dimethylamino-ethyl)-benzo[de]isoquin...)
Affinity DataIC50:  3.96E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188073(CHEMBL209433 | N-(2-(1H-indol-3-yl)ethyl)-2-chloro...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50037511(8-Amino-10H-isoindolo[1,2-b]quinazolin-12-one | CH...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188064(CHEMBL209467 | N-(2-(1H-indol-3-yl)ethyl)-4-tert-b...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188068(CHEMBL213449 | N-(2-(1H-indol-3-yl)ethyl)-4-fluoro...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188078(CHEMBL377131 | N-(2-(1H-indol-3-yl)ethyl)-N,4-dime...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50003677(4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid...)
Affinity DataIC50:  6.51E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188072(CHEMBL209972 | N-(2-(1H-indol-3-yl)ethyl)-3-bromo-...)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM67690(1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis...)
Affinity DataIC50:  7.63E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188067(CHEMBL376003 | N-(2-(1H-indol-3-yl)ethyl)-N,3-dime...)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188079(CHEMBL213036 | N-(2-(1H-indol-3-yl)ethyl)-2-methox...)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188081(CHEMBL213032 | N-(2-(1H-indol-3-yl)ethyl)-3-methox...)
Affinity DataIC50:  8.10E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188074(CHEMBL212768 | N-(2-(1H-indol-3-yl)ethyl)-N-methyl...)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188070(CHEMBL211622 | N-(2-(1H-indol-3-yl)ethyl)-3-fluoro...)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154457(3-(6-amino-8a-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,...)
Affinity DataIC50:  9.43E+4nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188077(CHEMBL211636 | N-(2-(1H-indol-3-yl)ethyl)-2-bromo-...)
Affinity DataIC50:  9.50E+4nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188065(CHEMBL374207 | N-(2-(1H-indol-3-yl)ethyl)-2-fluoro...)
Affinity DataIC50:  1.03E+5nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188076(CHEMBL214188 | N-(2-(1H-indol-3-yl)ethyl)-3-chloro...)
Affinity DataIC50:  1.09E+5nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50188080(CHEMBL214008 | N-(2-(1H-indol-3-yl)ethyl)-N,2-dime...)
Affinity DataIC50:  1.13E+5nMAssay Description:Inhibition of Cdk4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50028411(3-Methoxy-13-methyl-4-nitro-6,7,8,9,11,12,13,14,15...)
Affinity DataIC50:  1.96E+5nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Leicester

Curated by ChEMBL
LigandPNGBDBM50154464(2-Amino-5-(3-amino-propyl)-6-phenyl-pyrimidin-4-ol...)
Affinity DataIC50:  2.34E+5nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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