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Found 74 with Last Name = 'marino' and Initial = 'd'
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075292((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[3-(3-p...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075271((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  1.30nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075283((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  1.40nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(MOUSE)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075278(CHEMBL147319 | methyl 6-amino-2-[2-(1H-3-indolyl)-...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity of the compound was evaluated against mouse Somatostatin receptor type 2 (mSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075273((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  2.10nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 2 in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075286((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[3-meth...)
Affinity DataKi:  2.20nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075275((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  3.60nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075290((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3...)
Affinity DataKi:  4.60nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075276((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  5.90nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075280((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 2 in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075279((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3...)
Affinity DataKi:  7.30nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075272((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3...)
Affinity DataKi:  8.5nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 2 in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075272((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3...)
Affinity DataKi:  8.5nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(MOUSE)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075289(1-[5-amino-1-methyloxycarbonyl-(1R)-pentylcarbamoy...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity of the compound was evaluated against mouse Somatostatin receptor type 2 (mSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(MOUSE)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075274(1'N-[1-(5-aminopentylcarbamoyl)-2-(1H-3-indolyl)-(...)
Affinity DataKi: >10nMAssay Description:In vitro binding affinity of the compound was evaluated against mouse Somatostatin receptor type 2 (mSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(MOUSE)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075281(1'N-[1-(5-aminopentylcarbamoyl)-2-(1H-3-indolyl)-(...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity of the compound was evaluated against mouse Somatostatin receptor type 2 (mSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075277((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  11nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075293((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[3-(1-m...)
Affinity DataKi:  12nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075287((R)-6-Amino-2-[(2R,3S)-2-(3-benzyl-2-oxo-imidazoli...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075273((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 2 in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075284((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075280((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  40nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075285((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  40nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075288((R)-6-Amino-2-[(2R,3S)-3-(1H-indol-3-yl)-2-(2-oxo-...)
Affinity DataKi:  47nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075282((R)-6-Amino-2-[(2R,3S)-2-(3-biphenyl-3-yl-2-oxo-im...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075275((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  83nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 4 (hSSTR-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075291((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  122nMAssay Description:In vitro binding affinity was evaluated against human Somatostatin receptor type 2 (hSSTR-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075275((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  284nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 5 (hSSTR-5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075275((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  712nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 1 (hSSTR-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075275((R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-...)
Affinity DataKi:  1.29E+3nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 3 (hSSTR-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075273((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  1.40E+3nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 5 (hSSTR-5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075273((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity of the compound was evaluated against human Somatostatin receptor type 3 (hSSTR-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099023(CHEMBL11149 | N-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192278((2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluor...)
Affinity DataIC50:  24nMAssay Description:Inhibition of NK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097007(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50:  27nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191814((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of NK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099028(1-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]...)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191813((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluor...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099017(4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-et...)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099025(CHEMBL11011 | N-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192275((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of [125I]MCP1 binding to CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099022(CHEMBL268479 | N-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)...)
Affinity DataIC50:  47nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099024(1-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]...)
Affinity DataIC50:  48nMAssay Description:Inhibition of rat GnRH receptor bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191813((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluor...)
Affinity DataIC50:  50nMAssay Description:Inhibition of NK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191814((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of [125I]MCP1 binding to CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192278((2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluor...)
Affinity DataIC50:  72nMAssay Description:Inhibition of CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191813((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluor...)
Affinity DataIC50:  80nMAssay Description:Inhibition of [125I]MCP1 binding to CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192270((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of [125I]MCP1 binding to CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192271(CHEMBL211092 | trans-(S)-N-(3,5-bis(trifluoromethy...)
Affinity DataIC50:  140nMAssay Description:Inhibition of [125I]MCP1 binding to CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50192278((2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluor...)
Affinity DataIC50:  150nMAssay Description:Inhibition of [125I]MCP1 binding to CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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