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Found 1156 with Last Name = 'martin' and Initial = 'sw'
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109179(4-[3-(3-{3-[4-(3-Hydroxy-phenyl)-piperidin-1-yl]-p...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109122(4-[3-(3-{3-[4-(3-Methoxy-phenyl)-piperidin-1-yl]-p...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109188(4-[3-(3-{3-[4-(2-Methoxy-phenyl)-piperidin-1-yl]-p...)
Affinity DataKi:  4.10nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315675(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)py...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315688(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315674(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)py...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315676(((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-p...)
Affinity DataKi: >5.30nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315686(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315677(((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315680(((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315681(((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrroli...)
Affinity DataKi: >7.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378743(CHEMBL1204061)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315679(((3R,4S)-1-cyclopropyl-4-(2,4-difluorophenyl)pyrro...)
Affinity DataKi: >9.20nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109182(4-(3-{3-[3-(4-Cyclohexyl-piperidin-1-yl)-propyl]-u...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315673(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315669(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-4-yl)...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315692(CHEMBL1090488 | CHEMBL1204059)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315691(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109186(2,6-Dimethyl-4-(3-{3-[3-(4-phenyl-piperidin-1-yl)-...)
Affinity DataKi:  10nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378748(CHEMBL1204054)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315673(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109185(4-[3-(3-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-p...)
Affinity DataKi:  12nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  15nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315692(CHEMBL1090488 | CHEMBL1204059)
Affinity DataKi:  27nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378743(CHEMBL1204061)
Affinity DataKi:  36nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315676(((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-p...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109194(4-[3-(3-{3-[4-(3-Hydroxy-phenyl)-piperazin-1-yl]-p...)
Affinity DataKi:  37nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315691(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315674(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)py...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315672(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378748(CHEMBL1204054)
Affinity DataKi:  56nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315677(((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315669(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-4-yl)...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109173(2,6-Dimethyl-4-(3-{3-[3-(4-phenyl-piperazin-1-yl)-...)
Affinity DataKi:  66nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315675(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)py...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109193(4-(3-{3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-ureid...)
Affinity DataKi:  84nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109178(2,6-Dimethyl-4-(3-{3-[3-(4-phenyl-piperidin-1-yl)-...)
Affinity DataKi:  89nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109183(2,6-Dimethyl-4-(3-{3-[3-(4-o-tolyl-piperazin-1-yl)...)
Affinity DataKi:  96nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315689(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  97nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315688(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  99nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109192(4-[3-(3-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-p...)
Affinity DataKi:  105nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378746(CHEMBL1204065)
Affinity DataKi:  107nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109180(4-[3-(3-{3-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-p...)
Affinity DataKi:  108nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315681(((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrroli...)
Affinity DataKi:  114nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)
Affinity DataKi:  172nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315687(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  176nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50109181(4-(3-{3-[3-(4-Biphenyl-3-yl-piperidin-1-yl)-propyl...)
Affinity DataKi:  188nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)
Affinity DataKi:  233nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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