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Found 155 with Last Name = 'mccoy' and Initial = 'd'
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of CXCR4-mediated chemotaxis in SDF1-stimulated human U937 cells treated 15 mins before SDF1 challenge measured after 2 hrs by luminescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  0.870nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced response treated 30 mins before agonist challenge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  1.07nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced response treated before agonist challenge measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  1.71nMAssay Description:Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assay in presence of 45 mg/ml human ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  1.97nMAssay Description:Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assay in presence of alpha-acid glyc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1 group M subtyp...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  1.99nMAssay Description:Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assay in presence of 1 mg/ml alpha-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at mouse CXCR4 expressed in human U2OS cells assessed as inhibition of SDF1-induced increase in intracellular calcium level by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  2.41nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced increase in intracellular calcium level treated 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  3.36nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced response treated before agonist challenge measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Rattus norvegicus (Rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  4.30nMAssay Description:Antagonist activity at rat CXCR4 expressed in human U2OS cells assessed as inhibition of SDF1-induced increase in intracellular calcium level by FLIP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  6.60nMAssay Description:Antagonist activity at human CXCR4 expressed in human U2OS cells assessed as inhibition of SDF1-induced increase in intracellular calcium level by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Macaca mulatta)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  7.80nMAssay Description:Antagonist activity at monkey CXCR4 expressed in human U2OS cells assessed as inhibition of SDF1-induced increase in intracellular calcium level by F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of rat FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  26.6nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced response treated 30 mins before agonist challenge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  79nMAssay Description:Inhibition of human FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50:  193nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <1.58E+4nMAssay Description:Antagonist activity at human CaV1.2 channel expressed in HEK293 cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <1.58E+4nMAssay Description:Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium level by fluorescence/summary (Abse5) as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <1.58E+4nMAssay Description:Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as intracellular calcium level by fluorescence/summary (Abse5) as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Binding affinity to human PPARgamma by SPA/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Binding affinity to human PPARalpha by SPA/Abse5 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of human PI3K gamma by TR-FRET/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of human PDE4B by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Antagonist activity at human MC4 receptor assessed as cAMP level by HTRF LANCE/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Binding affinity to human PPARdelta by SPA/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Binding affinity to human PPARdelta by SPA/Abse5 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Binding affinity to human PPARalpha by SPA/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Binding affinity to human PPARgamma by SPA/Abse5 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of human FFA1 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-2B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Antagonist activity at human ACVR2B by Ant A204 luciferase reporter/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of human GSK3B by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.02E+4nMAssay Description:Antagonist activity at human dopamine D2 receptor by GTPgS SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.16E+4nMAssay Description:Antagonist activity at human GPR41 expressed in U2OS cells by brilliant black FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.16E+4nMAssay Description:Antagonist activity at human dopamine D2 receptor by GTPgS SPA/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.16E+4nMAssay Description:Antagonist activity at human beta 2 adrenergic receptor by TR FRET/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.16E+4nMAssay Description:Antagonist activity at human 5-HT1B receptor by LEADseeker GTPgS/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Blocking of human TRPM5 expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Blocking of human TRPC3 expressed in HEK cells by MSRII FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 2 member 16(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human TAS2R16 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 2 member 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human TAS2R14 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Inhibition of mouse SGLT3b expressed in U2OS cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Inhibition of human SGLT1 expressed in U2OS cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 15 member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human PePT1 receptor expressed in HEK cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human histamine H1 receptor by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human adrenergic alpha1B receptor assessed as intracellular calcium by summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human 5-HT2C receptor expressed in CHO cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in HEK cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: <3.98E+4nMAssay Description:Antagonist activity at human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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