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Found 70 with Last Name = 'mcmeekin' and Initial = 'p'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM591((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  0.900nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM591((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041945(1N-ethyl-2-benzylcarboxamido-2-[4-{2-[2-benzylcarb...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM658((3R,4R)-N-(1H-1,3-benzodiazol-2-yl)-4-{[(2R,4S)-2-...)
Affinity DataIC50:  3.80nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041946(1N-(2,2,2-trifluoroethyl)-2-benzylcarboxamido-2-[4...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM656((3R,4R)-N-benzyl-4-{[(2R,4S)-2-[(R)-(benzylcarbamo...)
Affinity DataIC50:  4.60nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037825(1N-ethyl-2-benzylcarboxamido-2-[4-{2-[2-benzylcarb...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM636((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM636((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  5nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041944(1N-benzyl-2-[4-{3-[2-benzylcarbamoyl(benzylcarboxa...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041949(4N-{2-[5-ethylcarbamoyl(5-methyl-3-phenyl-4-isoxaz...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041948(4N-{2-[5-ethylcarbamoyl(2-phenylphenylcarboxamido)...)
Affinity DataIC50:  9.90nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037842(4N-(tert-butyl)-3-{3-[2-benzylcarbamoyl(benzylcarb...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037832((3S,4aS,8aS)-2-[(S)-3-({(2R,4S)-2-[Carbamoyl-((S)-...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037817((3S,4aS,8aS)-2-[(S)-3-({(2R,4S)-2-[Benzylcarbamoyl...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037833((3S,4aS,8aS)-2-[(S)-3-({(2R,4S)-2-[(4-Dimethylamin...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037819((3S,4aS,8aS)-2-[3-({(2R,4S)-2-[Ethylcarbamoyl-((S)...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037824(CHEMBL122641 | {(2R,4S)-4-[(S)-3-((3S,4aS,8aS)-3-t...)
Affinity DataIC50:  54nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50407257(CHEMBL2112601)
Affinity DataIC50:  58nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM654((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  69nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50407258(CHEMBL2111802)
Affinity DataIC50:  82nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM652((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  82nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037828((3S,4aS,8aS)-2-[3-({(2R,4S)-2-[Heptylcarbamoyl-((S...)
Affinity DataIC50:  86nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037835(3-[(R)-3-({(2R,4S)-2-[Benzylcarbamoyl-((S)-phenyla...)
Affinity DataIC50:  93nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037818(2-(3-{[5,5-Dimethyl-2-({2-[5-(2-oxo-hexahydro-thie...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM640((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  150nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037827(CHEMBL125827 | {2-[2-{(2R,4S)-4-[3-((3S,4aS,8aS)-3...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037841((3S,4aS,8aS)-2-[(R)-3-({(2R,4S)-2-[Benzylcarbamoyl...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM660((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  170nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM661((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  170nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM659((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  190nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037822(3-[(S)-3-({(2R,4S)-2-[Benzylcarbamoyl-((S)-phenyla...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM662((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  220nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM646((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  250nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM663((3R,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  300nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037834((3S,4aS,8aS)-2-[(R)-3-({(2R,4S)-2-[(Cyclohexylmeth...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041947(4N-{2-[5-ethylcarbamoyl(phenylcarboxamido)methyl-2...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037830((2R,4S)-2-[Benzylcarbamoyl-((S)-phenylacetylamino)...)
Affinity DataIC50:  450nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM635((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  540nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM647((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50: >540nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM635((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  540nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50041950(1N-benzyl-2-[4-{3-[2-benzylcarbamoyl(benzylcarboxa...)
Affinity DataIC50:  540nMAssay Description:Inhibitory activity against HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037836((2R,4S)-2-[Benzylcarbamoyl-((S)-phenylacetylamino)...)
Affinity DataIC50:  650nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037839((2R,4S)-2-[Ethylcarbamoyl-((S)-phenylacetylamino)-...)
Affinity DataIC50:  710nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037821((2R,4S)-2-[Ethylcarbamoyl-((S)-phenylacetylamino)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037829((2R,4S)-2-[Benzylcarbamoyl-((S)-phenylacetylamino)...)
Affinity DataIC50:  1.50E+3nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037826((2R,4S)-2-[Benzylcarbamoyl-((S)-phenylacetylamino)...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM651((3S,4R)-4-{[(2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phe...)
Affinity DataIC50:  1.90E+3nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037840((S)-1-[(R)-3-({(2R,4S)-2-[Benzylcarbamoyl-((S)-phe...)
Affinity DataIC50: >2.20E+3nMAssay Description:In vitro inhibitory activity against HIV proteinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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