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Found 168 with Last Name = 'mcmenamin' and Initial = 'rl'
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate additionMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataIC50:  0.0490nMAssay Description:Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrateMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataIC50:  0.0490nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataIC50:  0.0490nMAssay Description:Inhibition of recombinant human Lp-PLA2 incubated for 20 mins by Thio-PAF assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  1.40nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182422(CHEMBL3818650)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27083(1-(2,6-difluorophenyl)-3-{3-[5-(morpholin-4-ylmeth...)
Affinity DataIC50:  1.5nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182421(CHEMBL3817896)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27083(1-(2,6-difluorophenyl)-3-{3-[5-(morpholin-4-ylmeth...)
Affinity DataIC50:  2.60nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27082(1-(2-fluorophenyl)-3-{3-[5-(morpholin-4-ylmethyl)-...)
Affinity DataIC50:  2.80nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24644(4-N-(2,6-difluorobenzene)-3-N-(4-fluorophenyl)-1H-...)
Affinity DataIC50:  3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27079(N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  3.5nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182420(CHEMBL3819600)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27084(1-cyclohexyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3...)
Affinity DataIC50:  5.20nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27084(1-cyclohexyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3...)
Affinity DataIC50:  5.70nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27078(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ben...)
Affinity DataIC50:  5.90nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182419(CHEMBL3819444)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24644(4-N-(2,6-difluorobenzene)-3-N-(4-fluorophenyl)-1H-...)
Affinity DataIC50:  10nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27086(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  10nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27080(4-fluoro-N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-ben...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27082(1-(2-fluorophenyl)-3-{3-[5-(morpholin-4-ylmethyl)-...)
Affinity DataIC50:  10nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27081(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  12nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24646(3-N-cyclohexyl-4-N-(2,6-difluorobenzene)-1H-pyrazo...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27085(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  13nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27079(N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  15nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  17nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Astex

LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  18nMAssay Description:CDK5/p35 activity was determined in DELFIA format using a biotinylated Histone H1 peptide. The phosphorylated peptide was quantified using rabbit pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182422(CHEMBL3818650)
Affinity DataIC50:  18nMAssay Description:Inhibition of Lp-PLA2 in human whole plasma using 2-thio-PAF as substrate preincubated for 15 mins followed by substrate addition measured after 3 mi...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24647(4-N-(2,6-difluorobenzene)-3-N-(4-hydroxycyclohexyl...)
Affinity DataIC50:  19nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27085(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  24nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24645(3-N-(cyclopropylmethyl)-4-N-(2,6-difluorobenzene)-...)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27086(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  26nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182421(CHEMBL3817896)
Affinity DataIC50:  28nMAssay Description:Inhibition of Lp-PLA2 in human whole plasma using 2-thio-PAF as substrate preincubated for 15 mins followed by substrate addition measured after 3 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24633(5-[(4-aminocyclohexyl)amino]-7-(propan-2-ylamino)p...)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50197673(CHEMBL3922315)
Affinity DataIC50:  32nMAssay Description:Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate additionMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24652(4-N-(2-fluoro-6-methoxybenzene)-3-N-(piperidin-4-y...)
Affinity DataIC50:  35nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Lp-PLA2 in human whole plasma using 2-thio-PAF as substrate preincubated for 15 mins followed by substrate addition measured after 3 mi...More data for this Ligand-Target Pair
LigandPNGBDBM24650(4-N-(2,6-difluorobenzene)-3-N-[(3S)-piperidin-3-yl...)
Affinity DataIC50:  38nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24648(3-N-(4-aminocyclohexyl)-4-N-(2,6-difluorobenzene)-...)
Affinity DataIC50:  38nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24650(4-N-(2,6-difluorobenzene)-3-N-[(3S)-piperidin-3-yl...)
Affinity DataIC50:  44nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24647(4-N-(2,6-difluorobenzene)-3-N-(4-hydroxycyclohexyl...)
Affinity DataIC50:  45nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  47nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM27078(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ben...)
Affinity DataIC50:  52nMAssay Description:CDK2/cyclinA activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1. ...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27081(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  54nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24646(3-N-cyclohexyl-4-N-(2,6-difluorobenzene)-1H-pyrazo...)
Affinity DataIC50:  55nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM27077(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ace...)
Affinity DataIC50:  70nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50197653(CHEMBL3985490)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astex

LigandPNGBDBM27080(4-fluoro-N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-ben...)
Affinity DataIC50:  75nMpH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50197658(CHEMBL3897162)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50197651(CHEMBL3957888)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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