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Found 84 with Last Name = 'mcnaughton' and Initial = 'm'
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataKi:  136nM ΔG°:  -38.8kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25398(Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...)
Affinity DataKi:  311nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25398(Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...)
Affinity DataKi:  436nM ΔG°:  -35.9kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25396(Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...)
Affinity DataKi:  863nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25397((2R,3R,4S,5R)-2-{6-[(4-{[2-(3-amino-4-hydroxypheny...)
Affinity DataKi:  1.01E+3nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25399(Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...)
Affinity DataKi:  1.91E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25396(Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...)
Affinity DataKi:  1.91E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25394(Bivalent derivative, 12a | N-[5-(2-{[2-({9-[(2R,3R...)
Affinity DataKi:  1.98E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25399(Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...)
Affinity DataKi:  2.30E+3nM ΔG°:  -31.9kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50371003(CHEMBL397507)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Monash University

LigandPNGBDBM25395((2R,3R,4S,5R)-2-{6-[(2-{[2-(3-amino-4-hydroxypheny...)
Affinity DataKi:  2.75E+3nM ΔG°:  -31.4kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25397((2R,3R,4S,5R)-2-{6-[(4-{[2-(3-amino-4-hydroxypheny...)
Affinity DataKi:  4.31E+3nM ΔG°:  -30.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50234567(1,4-dideoxy-1,4-imino-D-ribitol | CHEMBL261634 | I...)
Affinity DataKi:  6.10E+3nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260497(1,4-Dideoxy-1,4-imino-N-(4-amidinobenzyl)-D-ribito...)
Affinity DataKi:  6.70E+3nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260496(1,4-Dideoxy-1,4-imino-N-(4-guanidinobenzyl)-D-ribi...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25395((2R,3R,4S,5R)-2-{6-[(2-{[2-(3-amino-4-hydroxypheny...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25394(Bivalent derivative, 12a | N-[5-(2-{[2-({9-[(2R,3R...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260490((1S )-1,4-Dideoxy-1-(2-guanidinoethyl)-1,4-imino-D...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50370996(CHEMBL230908)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50370998(CHEMBL397508)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50371000(CHEMBL231322)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260492(1,4-Dideoxy-(3-guanidinopropyl)-1,4-imino-D-ribito...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50377915(CHEMBL1169558)
Affinity DataKi:  5.90E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50371001(CHEMBL395797)
Affinity DataKi:  6.30E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50371002(CHEMBL230061)
Affinity DataKi:  8.70E+4nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260491(1,4-Dideoxy-(2-guanidinoethyl)-1,4-imino-D-ribitol...)
Affinity DataKi:  2.86E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260487(1-Guanidino-3,6-anhydro-1,2-dideoxy-Dallo-heptitol...)
Affinity DataKi:  3.09E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50370999(CHEMBL231025)
Affinity DataKi:  5.20E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260486(1-Guanidino-2,5-anhydro-1-deoxy-D-allitol | CHEMBL...)
Affinity DataKi:  5.45E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260489(1-Guanidino-4,7-anhydro-1,2,3-trideoxy-Dallo-octit...)
Affinity DataKi:  6.77E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50370997(CHEMBL425996)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260488(2-Guanidino-4,7-anhydro-1,2,3-trideoxy-Dallo-octit...)
Affinity DataKi:  6.85E+5nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260485(2,5-Anhydro-1-deoxy-1-(trimethylammonio)-D-allitol...)
Affinity DataKi:  1.28E+6nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50260480((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-tetr...)
Affinity DataKi:  4.50E+6nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50206267((2S,3R,4S,5R)-2-(2-azidoethyl)-5-(hydroxymethyl)-t...)
Affinity DataKi:  5.60E+6nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIAG-nucleoside hydrolase(Trypanosoma vivax)
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50206267((2S,3R,4S,5R)-2-(2-azidoethyl)-5-(hydroxymethyl)-t...)
Affinity DataKi:  5.64E+6nMAssay Description:Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459192(CHEMBL4205724)
Affinity DataIC50:  50nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50474574(CHEMBL217200)
Affinity DataIC50:  260nMAssay Description:Inhibition of thioredoxin reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50474575(CHEMBL412348)
Affinity DataIC50:  500nMAssay Description:Inhibition of thioredoxin reductase in the presence of thioredoxinand insulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50474576(CHEMBL413290)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of thioredoxin reductase in the presence of thioredoxinand insulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459193(CHEMBL4212403)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459193(CHEMBL4212403)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50474579(CHEMBL440625)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of thioredoxin reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50474573(CHEMBL385299)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of thioredoxin reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459193(CHEMBL4212403)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459193(CHEMBL4212403)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50474575(CHEMBL412348)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of thioredoxin reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459192(CHEMBL4205724)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cistim Leuven

Curated by ChEMBL
LigandPNGBDBM50459192(CHEMBL4205724)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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