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Found 60 with Last Name = 'mitchell' and Initial = 'k'
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  2.90nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  4.60nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  46nMT: 2°CAssay Description:For WT IDH1 and IDH2, reactions were conducted at room temperature in 384-well Greiner black microtiter plates in a total volume of 10 μL of ass...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291107((3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  100nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291110(CHEMBL136011 | Methyl-(1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50:  180nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291111((6,7-Dimethoxy-quinazolin-4-yl)-methyl-m-tolyl-ami...)
Affinity DataIC50:  180nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  496nMT: 2°CAssay Description:For WT IDH1 and IDH2, reactions were conducted at room temperature in 384-well Greiner black microtiter plates in a total volume of 10 μL of ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50:  500nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50:  500nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291103((6,7-Dimethoxy-quinazolin-4-yl)-methyl-(3-trifluor...)
Affinity DataIC50:  500nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50:  500nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291112(CHEMBL541334 | Methyl-phenyl-(1H-pyrazolo[3,4-d]py...)
Affinity DataIC50:  600nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R172S](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  1.03E+3nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  1.36E+3nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291107((3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291109((6,7-Dimethyl-quinazolin-4-yl)-methyl-m-tolyl-amin...)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291116((6,7-Dimethoxy-quinazolin-4-yl)-methyl-p-tolyl-ami...)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291115(CHEMBL335052 | Methyl-phenyl-(9H-purin-6-yl)-amine)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291114((4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290633(4-(2,3-Dihydro-indol-1-yl)-6,7-dimethoxy-quinazoli...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291114((4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291116((6,7-Dimethoxy-quinazolin-4-yl)-methyl-p-tolyl-ami...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291115(CHEMBL335052 | Methyl-phenyl-(9H-purin-6-yl)-amine)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291102((6,7-Dimethoxy-quinazolin-4-yl)-ethyl-phenyl-amine...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195602(GSK990)
Affinity DataIC50:  4.50E+3nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291106((2,6-Dichloro-quinazolin-4-yl)-methyl-phenyl-amine...)
Affinity DataIC50:  5.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290633(4-(2,3-Dihydro-indol-1-yl)-6,7-dimethoxy-quinazoli...)
Affinity DataIC50:  5.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291102((6,7-Dimethoxy-quinazolin-4-yl)-ethyl-phenyl-amine...)
Affinity DataIC50:  5.50E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291109((6,7-Dimethyl-quinazolin-4-yl)-methyl-m-tolyl-amin...)
Affinity DataIC50:  6.50E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195602(GSK990)
Affinity DataIC50:  1.09E+4nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291111((6,7-Dimethoxy-quinazolin-4-yl)-methyl-m-tolyl-ami...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291105((6,8-Dimethyl-quinazolin-4-yl)-methyl-phenyl-amine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291104((6-Methoxy-quinazolin-4-yl)-methyl-phenyl-amine; h...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291101(CHEMBL545302 | Methyl-phenyl-(6,7,8-trimethoxy-qui...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291104((6-Methoxy-quinazolin-4-yl)-methyl-phenyl-amine; h...)
Affinity DataIC50:  2.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3260(4-Anilino quinazoline deriv. 11 | N-methyl-N-pheny...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291105((6,8-Dimethyl-quinazolin-4-yl)-methyl-phenyl-amine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291106((2,6-Dichloro-quinazolin-4-yl)-methyl-phenyl-amine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291101(CHEMBL545302 | Methyl-phenyl-(6,7,8-trimethoxy-qui...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195602(GSK990)
Affinity DataIC50:  2.33E+4nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291103((6,7-Dimethoxy-quinazolin-4-yl)-methyl-(3-trifluor...)
Affinity DataIC50:  3.00E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291117(CHEMBL135928 | Methyl-phenyl-(2,6,7-trimethoxy-qui...)
Affinity DataIC50: >5.00E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291117(CHEMBL135928 | Methyl-phenyl-(2,6,7-trimethoxy-qui...)
Affinity DataIC50: >5.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: >5.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291108((2-Chloro-6,7-dimethoxy-quinazolin-4-yl)-methyl-ph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
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