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Found 601 with Last Name = 'miyagi' and Initial = 't'
TargetSialidase-2(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50295841(4-Acetamido-5-(biphenyl-4-ylcarboxamido)-2-fluorob...)
Affinity DataKi:  3.07E+5nMAssay Description:Inhibition of human NEU2 transiently transfected in HEK293 cells by Line-Weaver Burk plottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/28/2005(H6N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/67/2005(H1N1)) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/394/2005(H5N3)) neuraminidase N3 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/20/2007(H8N4)) neuraminidase N4 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50452874(CHEMBL4217620)
Affinity DataIC50:  0.600nMAssay Description:Binding affinity to human recombinant BACE-1 (1 to 460 residue) using CEVNLDAEFK as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/700/2007(H7N7)) neuraminidase N7 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261482(US10011568, Ex. No. 5 | US9708266, 5)
Affinity DataIC50:  0.980nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261482(US10011568, Ex. No. 5 | US9708266, 5)
Affinity DataIC50:  0.980nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  1nMAssay Description:Inhibition of Influenza A virus (A/duck/Shiga/8/2004(H4N6)) neuraminidase N6 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261483(US10011568, Ex. No. 6 | US9708266, 6)
Affinity DataIC50:  1nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261483(US10011568, Ex. No. 6 | US9708266, 6)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362778(CHEMBL1940182)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Influenza A virus A/duck/Tsukuba/441/05(H11N9) neuraminidase N9 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Influenza A virus A/Yamaguchi/20/06(H1N1) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM292016(US10100030, Example 11)
Affinity DataIC50:  1.32nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 uL/well. DMSO solutions of a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261478(US10011568, Ex. No. 1 | US9708266, 1)
Affinity DataIC50:  1.45nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261478(US10011568, Ex. No. 1 | US9708266, 1)
Affinity DataIC50:  1.45nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344664(6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Miyagi Cancer Center Research Institute

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  1.56nMAssay Description:Inhibition of human Influenza A virus A/PR/8/34(H1N1) neuraminidase by fluorometric method using 4MU-NeuAc substrateMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Influenza A virus (A/California/04/2009(H1N1)) neuraminidase N1 V149I mutant activity using 4MU-Neu5Ac as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (strain A/Aichi/2/1968 H3N2))
Miyagi Cancer Center Research Institute

Curated by ChEMBL
LigandPNGBDBM4994((3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)c...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human influenza A virus A/Aichi/2/1968(H3N2) neuraminidase by fluorometric method using 4MU-NeuAc substrateMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261490(US10011568, Ex. No. 13 | US9708266, 13)
Affinity DataIC50:  1.62nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261490(US10011568, Ex. No. 13 | US9708266, 13)
Affinity DataIC50:  1.62nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261484(US10011568, Ex. No. 7 | US9708266, 7)
Affinity DataIC50:  1.63nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261484(US10011568, Ex. No. 7 | US9708266, 7)
Affinity DataIC50:  1.63nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Influenza A virus (A/mallard/Hokkaido/24/2009(H5N1)) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261479(US10011568, Ex. No. 2 | US9708266, 2)
Affinity DataIC50:  1.78nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261479(US10011568, Ex. No. 2 | US9708266, 2)
Affinity DataIC50:  1.78nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Influenza A virus (A/Aichi/102/2008(H3N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Influenza A virus (A/Narita/1/2009(H1N1)) neuraminidase N1 V149I mutant activity using 4MU-Neu5Ac as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182249(CHEMBL3818159)
Affinity DataIC50:  2nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/20/2007(H8N4)) neuraminidase N4 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM160321(US9040693, 22)
Affinity DataIC50:  2nMT: 2°CAssay Description:Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261480(US10011568, Ex. No. 3 | US9708266, 3)
Affinity DataIC50:  2.10nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261480(US10011568, Ex. No. 3 | US9708266, 3)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM292006(US10100030, Example 1)
Affinity DataIC50:  2.11nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 uL/well. DMSO solutions of a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of Influenza A virus A/duck/Chiba/13/06(H12N5) neuraminidase N5 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261491(US10011568, Ex. No. 14 | US9708266, 14)
Affinity DataIC50:  2.21nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261491(US10011568, Ex. No. 14 | US9708266, 14)
Affinity DataIC50:  2.21nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM292013(US10100030, Example 8)
Affinity DataIC50:  2.25nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 uL/well. DMSO solutions of a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/394/2005(H5N3)) neuraminidase N3 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261481(US10011568, Ex. No. 4 | US9708266, 4)
Affinity DataIC50:  2.35nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261486(US10011568, Ex. No. 9 | US9708266, 9)
Affinity DataIC50:  2.35nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261481(US10011568, Ex. No. 4 | US9708266, 4)
Affinity DataIC50:  2.35nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261486(US10011568, Ex. No. 9 | US9708266, 9)
Affinity DataIC50:  2.35nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261497(US10011568, Ex. No. 21 | US9708266, 21)
Affinity DataIC50:  2.36nMAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Kissei Pharmaceutical

US Patent
LigandPNGBDBM261497(US10011568, Ex. No. 21 | US9708266, 21)
Affinity DataIC50:  2.36nMpH: 7.4 T: 2°CAssay Description:The buffer solution for the receptor binding test was dispensed to the wells of a 96-well assay plate (Greiner) at 22.5 μL/well. DMSO solutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus)
Thammasat University

Curated by ChEMBL
LigandPNGBDBM50182248(CHEMBL3818654)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Influenza A virus (A/duck/Tsukuba/28/2005(H6N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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