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Found 286 with Last Name = 'mol' and Initial = 'cd'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50:  2.30nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31586(oxadiazole derivative, 20w)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31578(oxadiazole derivative, 20o)
Affinity DataIC50:  3.10nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31584(oxadiazole derivative, 20u)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31577(oxadiazole derivative, 20n)
Affinity DataIC50:  4.90nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355934(CHEMBL1910404)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31572(oxadiazole derivative, 20m)
Affinity DataIC50:  5.70nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31580(oxadiazole derivative, 20q)
Affinity DataIC50:  6.5nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321576(1-(4-(3-aminoazetidine-1-carbonyl)-5-(2-fluoro-4-i...)
Affinity DataIC50:  7nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31583(oxadiazole derivative, 20t)
Affinity DataIC50:  8.40nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31585(oxadiazole derivative, 20v)
Affinity DataIC50:  8.60nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31588(oxadiazole derivative, 20y)
Affinity DataIC50:  9.40nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321567((S)-5-acetyl-N-(2,3-dihydroxypropoxy)-2-(2-fluoro-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321561(1-acetyl-4-(2-fluoro-4-iodophenylamino)-N-(2-hydro...)
Affinity DataIC50:  11nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50361337(CHEMBL1933845)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-AD-5061 from human GST-tagged PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321572((S)-5-acetyl-4-chloro-N-(2,3-dihydroxypropoxy)-2-(...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355930(CHEMBL1910400)
Affinity DataIC50:  13nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31570(oxadiazole derivative, 20k)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321577((R)-1-(5-(2-fluoro-4-iodophenylamino)-4-(3-hydroxy...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299079(5-{3-[4-(Methylsulfinyl)phenyl]-1-benzofuran-5-yl}...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355928(CHEMBL1910398)
Affinity DataIC50:  15nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355929(CHEMBL1910399)
Affinity DataIC50:  15nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50361338(CHEMBL1933842)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-AD-5061 from human GST-tagged PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31579(oxadiazole derivative, 20p)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31581(oxadiazole derivative, 20r)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321564(5-acetyl-2-(2-fluoro-4-iodophenylamino)-N-(2-hydro...)
Affinity DataIC50:  18nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321570(5-acetyl-4-chloro-2-(2-fluoro-4-iodophenylamino)-N...)
Affinity DataIC50:  18nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321574((S)-5-acetyl-N-(2,3-dihydroxypropoxy)-4-fluoro-2-(...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321568(5-acetyl-N-(1,3-dihydroxypropan-2-yloxy)-2-(2-fluo...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321562(1-acetyl-4-(2-fluoro-4-iodophenylamino)-N-(2-hydro...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299083((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321566((R)-5-acetyl-N-(2,3-dihydroxypropoxy)-2-(2-fluoro-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50361340(CHEMBL1933822)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]-AD-5061 from human GST-tagged PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50361339(CHEMBL1933841)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]-AD-5061 from human GST-tagged PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31582(oxadiazole derivative, 20s)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31571(oxadiazole derivative, 20l)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321573((R)-5-acetyl-N-(2,3-dihydroxypropoxy)-4-fluoro-2-(...)
Affinity DataIC50:  29nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321575(1-(5-(2-fluoro-4-iodophenylamino)-4-(3-hydroxyazet...)
Affinity DataIC50:  30nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355934(CHEMBL1910404)
Affinity DataIC50:  32nMAssay Description:Inhibition of human ACC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321571((R)-5-acetyl-4-chloro-N-(2,3-dihydroxypropoxy)-2-(...)
Affinity DataIC50:  32nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50189617((3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbo...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299081((S)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299080((R)-5-(5-methylfuran-2-yl)-3-(4-(methylsulfinyl)ph...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299082((R)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299084(2-{3-[4-(Ethylsulfonyl)phenyl]-1-benzofuran-5-yl}-...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM50299085(2-Methyl-5-{3-[4-(methylsulfonyl)phenyl]-1-benzofu...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50321563(5-acetyl-2-(2-fluoro-4-iodophenylamino)-1-methyl-1...)
Affinity DataIC50:  42nMAssay Description:Inhibition of MEK1 by cascade assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355923(CHEMBL1910393)
Affinity DataIC50:  43nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM31560(oxadiazole derivative, 20j)
Affinity DataIC50:  44nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50355931(CHEMBL1910401)
Affinity DataIC50:  45nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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