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Found 560 with Last Name = 'muegge' and Initial = 'i'
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302462(CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of soluble EH in human HepG2 cells by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(CHEMBL1083622 | N-(3,3-bis(4-fluorophenyl)propyl)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Rattus norvegicus)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  2nMAssay Description:Binding to Estrogen receptor- beta (ER beta) receptorMore data for this Ligand-Target Pair
TargetEstrogen receptor(RAT)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  2nMAssay Description:Binding to Estrogen receptor- alpha (ER alpha) receptorMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302475(CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human soluble EHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361634(CHEMBL1939877 | US8785489, (4-{[({5-[2-(ethoxycarb...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319986(CHEMBL1085743 | N-(3,3-bis(4-fluorophenyl)propyl)-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302475(CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319984(4-(pyrimidin-2-yloxy)-N-(2-(trifluoromethoxy)benzy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297414(CHEMBL556234 | N-[3-(4-Fluorophenyl)-3-(4-methanes...)
Affinity DataIC50:  4nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319986(CHEMBL1085743 | N-(3,3-bis(4-fluorophenyl)propyl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]-trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302461(CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302464(CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human soluble EHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297413(CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)
Affinity DataIC50:  4.80nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297415(CHEMBL564893 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297417(CHEMBL551338 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297402(CHEMBL563417 | N-[4,4-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297412(CHEMBL560740 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297416(4-Cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzam...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297396(CHEMBL556303 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302473(CHEMBL565628 | N-(3,3-diphenylpropyl)-6-(2,2,2-tri...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human soluble EHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302476(CHEMBL567283 | N-(2,4-dichlorobenzyl)-1-(2-ethoxye...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297400((S)-4-Cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulf...)
Affinity DataIC50:  6nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414745(CHEMBL2021549)
Affinity DataIC50:  6nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249878((R)-2-bromo-4,5-dimethoxy-N-(3-(1-methylpyrrolidin...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302464(CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297412(CHEMBL560740 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  6nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297414(CHEMBL556234 | N-[3-(4-Fluorophenyl)-3-(4-methanes...)
Affinity DataIC50:  6nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297400((S)-4-Cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulf...)
Affinity DataIC50:  6nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302474(CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human soluble EHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302471(CHEMBL565841 | N-(4-chlorobenzyl)-6-(3,3,3-trifluo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297417(CHEMBL551338 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(RAT)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  7nMAssay Description:Binding to Estrogen receptor- alpha (ER alpha) receptorMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297398(CHEMBL563216 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297413(CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human soluble EHMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319983(3-(pyridin-4-yl)-N-(2-(trifluoromethoxy)benzyl)pyr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414745(CHEMBL2021549)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297415(CHEMBL564893 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302462(CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297416(4-Cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzam...)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297413(CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297401(CHEMBL562081 | N-[3-(4-Fluorophenyl)-3-(4-methanes...)
Affinity DataIC50:  7nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297396(CHEMBL556303 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  7.20nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302474(CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297397(CHEMBL571898 | N-(3,3-Diphenyl-propyl)-isonicotina...)
Affinity DataIC50:  7.60nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302473(CHEMBL565628 | N-(3,3-diphenylpropyl)-6-(2,2,2-tri...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297397(CHEMBL571898 | N-(3,3-Diphenyl-propyl)-isonicotina...)
Affinity DataIC50:  7.90nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297399(CHEMBL564145 | N-[3-(4-Fluorophenyl)-3-(4-methanes...)
Affinity DataIC50:  8nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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