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Found 82 with Last Name = 'murthi' and Initial = 'k'
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  4nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128463((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phe...)
Affinity DataIC50: <5nMAssay Description:Inhibition of Candida albicans Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128465((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Candida albicans Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  7nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM10890(1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonam...)
Affinity DataIC50:  7nM EC50:  80nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128464((S)-2-((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Candida albicans Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataIC50:  14nM EC50:  40nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  15nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59253(RGB-285961)
Affinity DataIC50:  20nM EC50:  70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  22nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50:  28nM EC50: <3nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  34nMAssay Description:Inhibition of HCT116 cell proliferation with compounds using calcein AM Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  43nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  48nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  51nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  64nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDK-activating kinase assembly factor MAT1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  71nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  84nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  155nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128463((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phe...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Candida albicans FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  220nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  221nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  230nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  282nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  310nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  372nM EC50:  70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  410nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  485nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50088615(2-(4-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  550nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50088606(2-(2-Bromo-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  663nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  754nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50451015(CHEMBL9052)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50088612(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  839nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  858nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  890nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088606(2-(2-Bromo-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3...)
Affinity DataIC50:  980nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50451018(CHEMBL8675)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088612(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088610(2-(3-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50088608(2-(2,4-Dichloro-phenyl)-5,7-dihydroxy-8-(1-methyl-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088608(2-(2,4-Dichloro-phenyl)-5,7-dihydroxy-8-(1-methyl-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088615(2-(4-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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