Compile Data Set for Download or QSAR
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Found 65 with Last Name = 'nguyen' and Initial = 'pd'
TargetCytochrome P450 2B6(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  340nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  400nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as efavirenz 8-hydroxylation after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide 4-methylhydroxylation after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2C19(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin 4'-hydroxylation after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533513(CHEMBL4438252)
Affinity DataIC50:  41nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533516(CHEMBL4464661)
Affinity DataIC50:  49nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533522(CHEMBL4468920)
Affinity DataIC50:  55nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533495(CHEMBL4542476)
Affinity DataIC50:  62nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533496(CHEMBL4438330)
Affinity DataIC50:  63nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533525(CHEMBL4551156)
Affinity DataIC50:  66nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533510(CHEMBL4539358)
Affinity DataIC50:  67nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533494(CHEMBL4563281)
Affinity DataIC50:  85nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533523(CHEMBL4542775)
Affinity DataIC50:  86nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533490(CHEMBL4528625)
Affinity DataIC50:  87nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533508(CHEMBL4589298)
Affinity DataIC50:  87nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533515(CHEMBL4568142)
Affinity DataIC50:  92nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533526(CHEMBL4566648)
Affinity DataIC50:  94nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533524(CHEMBL4445058)
Affinity DataIC50:  110nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533504(CHEMBL4571882)
Affinity DataIC50:  110nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533499(CHEMBL4467879)
Affinity DataIC50:  112nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533517(CHEMBL4456986)
Affinity DataIC50:  114nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533529(CHEMBL4589083)
Affinity DataIC50:  121nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533498(CHEMBL4466262)
Affinity DataIC50:  148nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533497(CHEMBL4476368)
Affinity DataIC50:  163nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533514(CHEMBL4439113)
Affinity DataIC50:  175nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533505(CHEMBL4453897)
Affinity DataIC50:  179nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533527(CHEMBL4540107)
Affinity DataIC50:  195nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533518(CHEMBL4566050)
Affinity DataIC50:  208nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533491(CHEMBL4458457)
Affinity DataIC50:  216nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533500(CHEMBL4468626)
Affinity DataIC50:  225nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533506(CHEMBL4571724)
Affinity DataIC50:  229nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533521(CHEMBL4526971)
Affinity DataIC50:  270nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533528(CHEMBL4590845)
Affinity DataIC50:  272nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533501(CHEMBL4483757)
Affinity DataIC50:  280nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533520(CHEMBL4561383)
Affinity DataIC50:  289nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533507(CHEMBL4439618)
Affinity DataIC50:  294nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533493(CHEMBL4456369)
Affinity DataIC50:  362nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533509(CHEMBL4465134)
Affinity DataIC50:  394nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533502(CHEMBL4449698)
Affinity DataIC50:  475nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533487(CHEMBL4583737)
Affinity DataIC50:  766nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533511(CHEMBL4482957)
Affinity DataIC50:  771nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50:  790nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as 8-hydroxyefavirenz 14-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533488(CHEMBL4580050)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533489(CHEMBL4442422)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533492(CHEMBL4517543)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533503(CHEMBL4535130)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533512(CHEMBL4458399)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533519(CHEMBL4545908)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50533530(CHEMBL4581872)
Affinity DataIC50: >1.00E+3nMAssay Description:Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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