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Found 162 with Last Name = 'nimz' and Initial = 'o'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333952(CHEMBL1644470 | exo-(1R,5S)-3-(6-phenylpyridin-2-y...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333972(CHEMBL1644605 | exo-2-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataKi:  119nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50418185(CHEMBL1761695)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333954(CHEMBL1644611 | exo-3-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataKi:  1.62E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333953(2-(3-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50418184(CHEMBL1761694)
Affinity DataKi:  5.01E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50418183(CHEMBL1761688)
Affinity DataKi:  6.31E+3nMAssay Description:Displacement of labeled-dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50418183(CHEMBL1761688)
Affinity DataKi:  6.31E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333976(CHEMBL1644609 | exo-2-(6-((1R,5S)-8-azabicyclo[3.2...)
Affinity DataKi:  7.08E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418189(CHEMBL1761696)
Affinity DataIC50:  0.158nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336144((1R,3S)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(tri...)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418961(CHEMBL1807877)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418959(CHEMBL1807875)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418188(CHEMBL1761693)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418185(CHEMBL1761695)
Affinity DataIC50:  1.26nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418981(CHEMBL1807878)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418193(CHEMBL1761700)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418965(CHEMBL1807883)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418187(CHEMBL1761691)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418194(CHEMBL1761702)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418964(CHEMBL1807882)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333975(CHEMBL1644608 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418960(CHEMBL1807876)
Affinity DataIC50:  5.01nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418202(CHEMBL1761706)
Affinity DataIC50:  5.01nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418196(CHEMBL1761704)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418184(CHEMBL1761694)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333976(CHEMBL1644609 | exo-2-(6-((1R,5S)-8-azabicyclo[3.2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418192(CHEMBL1761699)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418201(CHEMBL1761701)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333960(CHEMBL1644477 | exo-(1R,5S)-3-(3-iodophenoxy)-8-az...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418190(CHEMBL1761697)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418979(CHEMBL1807879)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418963(CHEMBL1807881)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333959(CHEMBL1644476 | exo-(1R,5S)-3-(3-bromophenoxy)-8-a...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333977(CHEMBL1644610 | exo-2-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418199(CHEMBL1761692)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333957(CHEMBL1644474 | exo-(1R,5S)-3-(3-chlorophenoxy)-8-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418973(CHEMBL1807958)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333966(CHEMBL1644483 | exo-3-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418200(CHEMBL1761689)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418186(CHEMBL1761690)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333952(CHEMBL1644470 | exo-(1R,5S)-3-(6-phenylpyridin-2-y...)
Affinity DataIC50:  26nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333969(CHEMBL1644602 | exo-(1R,5S)-3-(5-chlorobiphenyl-3-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333974(CHEMBL1644607 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  31nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50418984(CHEMBL1807959)
Affinity DataIC50:  39.8nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333956(CHEMBL1644473 | exo-(1R,5S)-3-(4-chlorophenoxy)-8-...)
Affinity DataIC50:  43nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333977(CHEMBL1644610 | exo-2-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataIC50:  48nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336151((1R,3S)-4-chloro-5-(4-fluorophenyl)-N-(3-hydroxycy...)
Affinity DataIC50:  50.1nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333978(CHEMBL1644471 | exo-(1R,5S)-3-phenoxy-8-azabicyclo...)
Affinity DataIC50:  54nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333973(CHEMBL1644606 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  60nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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