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Found 382 with Last Name = 'nomoto' and Initial = 'y'
TargetPhosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM50049055((R)-6-(4-Benzylamino-quinazolin-7-yl)-5-methyl-4,5...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117352(4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Affinity DataIC50:  10nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50132222(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM50049055((R)-6-(4-Benzylamino-quinazolin-7-yl)-5-methyl-4,5...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50132222(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231424((S)-3-(4-(4-(2,6-dicyanophenyl)piperazin-1-yl)phen...)
Affinity DataIC50:  19nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115302(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115335(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134907(4-[7-(2-Ethoxy-ethoxy)-6-methoxy-quinazolin-4-yl]-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115351(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134899(4-[7-Methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Affinity DataIC50:  20nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231422((S)-2-((R)-1-(3,5-dichlorophenylsulfonyl)pyrrolidi...)
Affinity DataIC50:  28nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118881(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  30nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50115347(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  30nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118880(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  30nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115347(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50132206(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50132206(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231417((S)-4-((1-carboxy-2-(4-(4-phenylpiperazin-1-yl)phe...)
Affinity DataIC50:  42nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM50049053(6-(4-Benzylamino-quinazolin-7-yl)-5-methyl-4,5-dih...)
Affinity DataIC50:  46nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115302(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Flt3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134903(4-(7-Allyloxy-6-methoxy-quinazolin-4-yl)-piperazin...)
Affinity DataIC50:  50nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115302(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM50049053(6-(4-Benzylamino-quinazolin-7-yl)-5-methyl-4,5-dih...)
Affinity DataIC50:  50nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115299(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115331(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134858(4-(7-Methoxy-6-prop-2-ynyloxy-quinazolin-4-yl)-pip...)
Affinity DataIC50:  60nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231430((S)-3-(4-(4-(5-acetylthiophen-2-yl)piperazin-1-yl)...)
Affinity DataIC50:  67nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231413((S)-3-(4-(4-(2-cyanophenyl)piperazin-1-yl)phenyl)-...)
Affinity DataIC50:  67nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231419((S)-3-(4-(4-(2-nitrophenyl)piperazin-1-yl)phenyl)-...)
Affinity DataIC50:  69nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118859(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  70nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134866(CHEMBL344091 | Methanesulfonic acid 7-methoxy-4-[4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134871(4-(7,8-Dihydro-[1,4]dioxino[2,3-g]quinazolin-4-yl)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134889(4-(6-Methoxy-7-prop-2-ynyloxy-quinazolin-4-yl)-pip...)
Affinity DataIC50:  70nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231412((S)-3-(4-(4-(pyrazin-2-yl)piperazin-1-yl)phenyl)-2...)
Affinity DataIC50:  75nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231423((S)-3-(4-(4-phenylpiperazin-1-yl)phenyl)-2-((S)-1-...)
Affinity DataIC50:  76nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134898(4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Affinity DataIC50:  80nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134882(4-[7-Methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Affinity DataIC50:  80nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50134874(4-(6,7-Diethoxy-quinazolin-4-yl)-piperazine-1-carb...)
Affinity DataIC50:  80nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >80nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115302(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115319(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231429((S)-3-(4-(4-(cyclopropanecarbonyl)piperazin-1-yl)p...)
Affinity DataIC50:  80nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118858(4-(6,7-Dimethoxy-quinazolin-4-yl)-2-methyl-piperaz...)
Affinity DataIC50:  80nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50115302(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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