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Found 224 with Last Name = 'oberer' and Initial = 'l'
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50104934(CHEMBL292625 | [4-(4-Bromo-phenylamino)-4'-methyl-...)
Affinity DataIC50:  0.5nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143734(3-({[1'-(2,4-Dimethyl-1-oxy-pyridine-3-carbonyl)-4...)
Affinity DataIC50:  0.600nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-Dimethyl-phenyl)-(4-diphenylamino-4'-methyl-[...)
Affinity DataIC50:  0.700nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143762((2,6-Dimethyl-phenyl)-[4'-methyl-4-(4-trifluoromet...)
Affinity DataIC50:  0.800nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143756((4,6-Dimethyl-pyrimidin-5-yl)-(4-diphenylamino-4'-...)
Affinity DataIC50:  1nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143762((2,6-Dimethyl-phenyl)-[4'-methyl-4-(4-trifluoromet...)
Affinity DataIC50:  1.10nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143757((2,4-Dimethyl-pyridin-3-yl)-(4-diphenylamino-4'-me...)
Affinity DataIC50:  1.10nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  1.40nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143761(CHEMBL61466 | [4-(4-Chloro-phenylamino)-4'-methyl-...)
Affinity DataIC50:  2nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143743(CHEMBL61536 | [4-(Benzyl-phenyl-amino)-4'-methyl-[...)
Affinity DataIC50:  2nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of HDAC3 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399042(CHEMBL2178812)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50104934(CHEMBL292625 | [4-(4-Bromo-phenylamino)-4'-methyl-...)
Affinity DataIC50:  2.20nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143756((4,6-Dimethyl-pyrimidin-5-yl)-(4-diphenylamino-4'-...)
Affinity DataIC50:  2.20nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143745(CHEMBL60225 | {4-[Benzyl-(4-bromo-phenyl)-amino]-4...)
Affinity DataIC50:  2.30nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143757((2,4-Dimethyl-pyridin-3-yl)-(4-diphenylamino-4'-me...)
Affinity DataIC50:  2.30nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143761(CHEMBL61466 | [4-(4-Chloro-phenylamino)-4'-methyl-...)
Affinity DataIC50:  2.40nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143735((2,6-Dichloro-phenyl)-(4-diphenylamino-4'-methyl-[...)
Affinity DataIC50:  2.40nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of HDAC1 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399045(CHEMBL2178809)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143736((2,6-Dimethyl-phenyl)-(4-diphenylamino-4'-methyl-[...)
Affinity DataIC50:  2.60nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143747((4,6-Dimethyl-2-pyridin-4-yl-pyrimidin-5-yl)-(4-di...)
Affinity DataIC50:  2.80nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143734(3-({[1'-(2,4-Dimethyl-1-oxy-pyridine-3-carbonyl)-4...)
Affinity DataIC50:  2.80nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143741((4,6-dimethyl-1-oxy-pyrimidin-5-yl)-(4-diphenylami...)
Affinity DataIC50:  2.90nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143764((2,4-Dimethyl-pyridin-3-yl)-(4-diphenylamino-[1,4'...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50299166((6aR,9R)-N,N-diethyl-4,6,6a,7,8,9-hexahydroindolo[...)
Affinity DataIC50:  3nMAssay Description:Inhibition of 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143740((4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methy...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50:  3.30nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143750((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50:  3.40nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143735((2,6-Dichloro-phenyl)-(4-diphenylamino-4'-methyl-[...)
Affinity DataIC50:  3.5nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143754((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Affinity DataIC50:  3.70nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143737(4-({[1'-(2,4-Dimethyl-1-oxy-pyridine-3-carbonyl)-4...)
Affinity DataIC50:  3.80nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143743(CHEMBL61536 | [4-(Benzyl-phenyl-amino)-4'-methyl-[...)
Affinity DataIC50:  5.10nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50299166((6aR,9R)-N,N-diethyl-4,6,6a,7,8,9-hexahydroindolo[...)
Affinity DataIC50:  6nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399044(CHEMBL2178810)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143745(CHEMBL60225 | {4-[Benzyl-(4-bromo-phenyl)-amino]-4...)
Affinity DataIC50:  6.20nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143764((2,4-Dimethyl-pyridin-3-yl)-(4-diphenylamino-[1,4'...)
Affinity DataIC50:  7.40nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143760((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Affinity DataIC50:  7.80nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143756((4,6-Dimethyl-pyrimidin-5-yl)-(4-diphenylamino-4'-...)
Affinity DataIC50:  7.90nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143747((4,6-Dimethyl-2-pyridin-4-yl-pyrimidin-5-yl)-(4-di...)
Affinity DataIC50:  7.90nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143735((2,6-Dichloro-phenyl)-(4-diphenylamino-4'-methyl-[...)
Affinity DataIC50:  7.90nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143747((4,6-Dimethyl-2-pyridin-4-yl-pyrimidin-5-yl)-(4-di...)
Affinity DataIC50:  7.90nMAssay Description:Antagonistic activity of the compound against human C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143744((4,6-Dimethyl-pyrimidin-5-yl)-(4-diphenylamino-[1,...)
Affinity DataIC50:  8.20nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399043(CHEMBL2178811)
Affinity DataIC50:  8.40nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143746((4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenyl...)
Affinity DataIC50:  8.5nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143754((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Affinity DataIC50:  8.90nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143733((2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino...)
Affinity DataIC50:  9nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143751((4-Diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-...)
Affinity DataIC50:  9.90nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143734(3-({[1'-(2,4-Dimethyl-1-oxy-pyridine-3-carbonyl)-4...)
Affinity DataIC50:  10.8nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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