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Found 140 with Last Name = 'ogilvie' and Initial = 'ww'
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10227(5-chloro-2-ethyl-7-methyl-13-[(pyridin-4-ylsulfany...)
Affinity DataIC50:  2.20nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM2058(2,8-disubstituted dipyridodiazepinone 41 | 2-Chlor...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10235(13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]methyl}-2-...)
Affinity DataIC50:  4.20nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10232(5-chloro-13-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10234(13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]methyl}-2-...)
Affinity DataIC50:  6.90nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10230(5-chloro-13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]m...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10233(13-[(1,3-benzoxazol-2-ylsulfanyl)methyl]-5-chloro-...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171982(4-[2-(7-Chloro-5-ethyl-10-methyl-11-oxo-10,11-dihy...)
Affinity DataIC50:  10nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10229(5-chloro-2-ethyl-7-methyl-13-{[(3-methylpyridin-4-...)
Affinity DataIC50:  11nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10236(5-chloro-2-cyclopropyl-13-{[(2,6-dimethylpyridin-4...)
Affinity DataIC50:  12nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171979(6-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  14nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171976(4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...)
Affinity DataIC50:  15nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171974(4-[2-(5-Ethyl-7-methoxy-10-methyl-11-oxo-10,11-dih...)
Affinity DataIC50:  15nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171971(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  17nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171973(3-Bromo-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihyd...)
Affinity DataIC50:  18nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171980(3-Ethyl-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihyd...)
Affinity DataIC50:  19nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171981(4-[2-(5-Ethyl-7,10-dimethyl-11-oxo-10,11-dihydro-5...)
Affinity DataIC50:  19nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171975(3-{4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H...)
Affinity DataIC50:  22nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171983(CHEMBL370699 | {4-[2-(5-Ethyl-10-methyl-11-oxo-10,...)
Affinity DataIC50:  23nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM2058(2,8-disubstituted dipyridodiazepinone 41 | 2-Chlor...)
Affinity DataIC50:  26nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10231(5-chloro-2-ethyl-7-methyl-13-[(pyrimidin-5-ylsulfa...)
Affinity DataIC50:  26nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171978(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  27nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10228(5-chloro-2-ethyl-7-methyl-13-{[(2-methylpyridin-4-...)
Affinity DataIC50:  27nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10230(5-chloro-13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]m...)
Affinity DataIC50:  60nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171977(5-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  60nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171984(6-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  63nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171982(4-[2-(7-Chloro-5-ethyl-10-methyl-11-oxo-10,11-dihy...)
Affinity DataIC50:  64nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10227(5-chloro-2-ethyl-7-methyl-13-[(pyridin-4-ylsulfany...)
Affinity DataIC50:  80nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171972(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  95nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10234(13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]methyl}-2-...)
Affinity DataIC50:  120nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171976(4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...)
Affinity DataIC50:  150nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10235(13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]methyl}-2-...)
Affinity DataIC50:  170nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171978(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  194nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171975(3-{4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H...)
Affinity DataIC50:  200nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171971(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  221nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10233(13-[(1,3-benzoxazol-2-ylsulfanyl)methyl]-5-chloro-...)
Affinity DataIC50:  230nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10236(5-chloro-2-cyclopropyl-13-{[(2,6-dimethylpyridin-4...)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171981(4-[2-(5-Ethyl-7,10-dimethyl-11-oxo-10,11-dihydro-5...)
Affinity DataIC50:  280nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171973(3-Bromo-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihyd...)
Affinity DataIC50:  300nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171974(4-[2-(5-Ethyl-7-methoxy-10-methyl-11-oxo-10,11-dih...)
Affinity DataIC50:  300nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50065866((2S,3S)-3-Allyl-2-benzyl-4-oxo-azetidine-1-carboxy...)
Affinity DataIC50:  300nMAssay Description:Compound was tested for its activity against human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10228(5-chloro-2-ethyl-7-methyl-13-{[(2-methylpyridin-4-...)
Affinity DataIC50:  310nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10232(5-chloro-13-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl...)
Affinity DataIC50:  320nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171983(CHEMBL370699 | {4-[2-(5-Ethyl-10-methyl-11-oxo-10,...)
Affinity DataIC50:  370nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171980(3-Ethyl-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihyd...)
Affinity DataIC50:  430nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171977(5-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  550nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50065877((2S,3S)-2-Benzyl-3-methoxy-4-oxo-azetidine-1-carbo...)
Affinity DataIC50:  900nMAssay Description:Compound was tested for its activity against human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171979(6-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataIC50:  1.10E+3nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50065871((2S,3S)-2-Benzyl-3-ethyl-4-oxo-azetidine-1-carboxy...)
Affinity DataIC50:  1.20E+3nMAssay Description:Compound was tested for its activity against human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50065868((S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid met...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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