TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 1.97nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 44.4nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
Affinity DataIC50: 48nM Kd: 29nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of biotin-labelled P4 peptide binding to MDM2 (25 to 109 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
Affinity DataIC50: 72nM Kd: 100nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 74.4nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 137nM Kd: 208nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
Affinity DataIC50: 138nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
Affinity DataIC50: 156nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
Affinity DataIC50: 167nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 175nMAssay Description:Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 195nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of biotin-labelled D-p53 binding to D-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
Affinity DataIC50: 203nM Kd: 435nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies
Riken Center For Life Science Technologies
Affinity DataIC50: 210nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies
Riken Center For Life Science Technologies
Affinity DataIC50: 230nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
Affinity DataIC50: 238nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 244nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:The compound was evaluated for its inhibitory activity towards Protein tyrosine phosphatase of CD45More data for this Ligand-Target Pair
Affinity DataIC50: 299nM Kd: 426nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies
Riken Center For Life Science Technologies
Affinity DataIC50: 350nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (The Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 353nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
Affinity DataIC50: 418nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies
Riken Center For Life Science Technologies
Affinity DataIC50: 420nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 453nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Max Planck Institute of Molecular Physiology
Max Planck Institute of Molecular Physiology
Affinity DataIC50: 500nMpH: 7.5Assay Description:A stock solution of 5 % DMSO (BioReagent for molecular biology, Sigma Aldrich) in water was prepared. The CK1 substrate peptide RRKDLHDDEEDEAMSITA (J...More data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
Affinity DataIC50: 529nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 565nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Riken (Institute Of Physical And Chemical Research)
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Max Planck Institute of Molecular Physiology
Max Planck Institute of Molecular Physiology
Affinity DataIC50: 600nMpH: 7.5Assay Description:A stock solution of 5 % DMSO (BioReagent for molecular biology, Sigma Aldrich) in water was prepared. The CK1 substrate peptide RRKDLHDDEEDEAMSITA (J...More data for this Ligand-Target Pair
Affinity DataIC50: 627nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies
Riken Center For Life Science Technologies
Affinity DataIC50: 630nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
Affinity DataIC50: 693nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair