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Found 434 with Last Name = 'osada' and Initial = 'h'
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217841(REVEROMYCIN A)
Affinity DataIC50:  1.97nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217841(REVEROMYCIN A)
Affinity DataIC50:  4.46nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479281(2,3-DIHYDROREVEROMYCIN A)
Affinity DataIC50:  17.5nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479274(4-HYDROXY REVEROMYCIN A)
Affinity DataIC50:  21.7nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479284(CHEMBL442945)
Affinity DataIC50:  36.9nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217935(CHEMBL114859)
Affinity DataIC50:  44.4nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Antibiotics Laboratory

LigandPNGBDBM84663(Piperazine moiety, 3)
Affinity DataIC50:  48nM Kd:  29nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50240296(CHEMBL4095506)
Affinity DataIC50:  52nMAssay Description:Inhibition of biotin-labelled P4 peptide binding to MDM2 (25 to 109 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Antibiotics Laboratory

LigandPNGBDBM84666(Piperazine moiety, 6)
Affinity DataIC50:  72nM Kd:  100nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217844(CHEMBL115953)
Affinity DataIC50:  74.4nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479277(2,3-DIHYDRO-5-EPIREVEROMYCIN A)
Affinity DataIC50:  88nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217935(CHEMBL114859)
Affinity DataIC50:  100nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Antibiotics Laboratory

LigandPNGBDBM84665(Piperazine moiety, 5)
Affinity DataIC50:  137nM Kd:  208nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM50282567(3,4-Dichlorophenyl boronic acid | 3,4-dichloro ben...)
Affinity DataIC50:  138nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217934(CHEMBL321686)
Affinity DataIC50:  140nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Riken Advanced Science Institute

LigandPNGBDBM86370(Juniferdin derivative, 1)
Affinity DataIC50:  156nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Riken Advanced Science Institute

LigandPNGBDBM86381(Juniferdin derivative, 13)
Affinity DataIC50:  167nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217844(CHEMBL115953)
Affinity DataIC50:  168nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  175nMAssay Description:Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217938(CHEMBL112182)
Affinity DataIC50:  195nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  195nMAssay Description:Inhibition of biotin-labelled D-p53 binding to D-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Antibiotics Laboratory

LigandPNGBDBM84662(4-Fuloro sulfonamide, C)
Affinity DataIC50:  203nM Kd:  435nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227634(MTH1 inhibitor, 121)
Affinity DataIC50:  210nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  215nMAssay Description:Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227638(MTH1 inhibitor, 132)
Affinity DataIC50:  230nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92722(Phenylboronic acid, 15)
Affinity DataIC50:  238nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217849(CHEMBL115317)
Affinity DataIC50:  244nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094938(5-Isopropoxy-2-(4-methylsulfanyl-pyridin-2-ylmetha...)
Affinity DataIC50:  280nMAssay Description:The compound was evaluated for its inhibitory activity towards Protein tyrosine phosphatase of CD45More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Antibiotics Laboratory

LigandPNGBDBM84664(Piperazine moiety, 4)
Affinity DataIC50:  299nM Kd:  426nMpH: 8.4Assay Description:Inhibitory activity of the compounds for CAII was measured and IC50 values were calculated from independent triplicated experiments. Kd values were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479282(CHEMBL505238)
Affinity DataIC50:  312nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227638(MTH1 inhibitor, 132)
Affinity DataIC50:  350nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucyl-tRNA synthetase(Rattus norvegicus)
Riken (The Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217839(CHEMBL327131)
Affinity DataIC50:  353nMAssay Description:Inhibitory concentration against Isoleucyl-tRNA synthetase (IleRS) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Mus musculus)
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50104684((4-Hexadecanoyl-3-hydroxy-5-oxo-2,5-dihydro-furan-...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Mus musculus)
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50104691(CHEMBL423508 | Diazo-[2-(4-hexadecanoyl-3-hydroxy-...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92718(Phenylboronic acid, 10)
Affinity DataIC50:  418nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227634(MTH1 inhibitor, 121)
Affinity DataIC50:  420nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479276(CHEMBL461144)
Affinity DataIC50:  433nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Riken Advanced Science Institute

LigandPNGBDBM86372(Juniferdin derivative, 3)
Affinity DataIC50:  453nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Max Planck Institute of Molecular Physiology

LigandPNGBDBM191572(6-(3-chlorophenyl)pteridine-2,4,7-triamine (15) | ...)
Affinity DataIC50:  500nMpH: 7.5Assay Description:A stock solution of 5 % DMSO (BioReagent for molecular biology, Sigma Aldrich) in water was prepared. The CK1 substrate peptide RRKDLHDDEEDEAMSITA (J...More data for this Ligand-Target Pair
TargetAcyl-protein thioesterase 1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92717(Phenylboronic acid, 8)
Affinity DataIC50:  510nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Mus musculus)
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50104690((4-Hexadecanoyl-3-hydroxy-5-oxo-2,5-dihydro-furan-...)
Affinity DataIC50:  520nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM26139(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)
Affinity DataIC50:  529nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50217849(CHEMBL115317)
Affinity DataIC50:  554nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Riken Advanced Science Institute

LigandPNGBDBM86380(Juniferdin derivative, 10)
Affinity DataIC50:  565nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Riken (Institute Of Physical And Chemical Research)

Curated by ChEMBL
LigandPNGBDBM50479275(5-EPIREVEROMYCIN A)
Affinity DataIC50:  572nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Mus musculus)
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50104674((4-Hexadecanoyl-3-hydroxy-5-oxo-2,5-dihydro-furan-...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Max Planck Institute of Molecular Physiology

LigandPNGBDBM191587(6-(1-benzothiophen-3-yl)pteridine-2,4,7-triamine (...)
Affinity DataIC50:  600nMpH: 7.5Assay Description:A stock solution of 5 % DMSO (BioReagent for molecular biology, Sigma Aldrich) in water was prepared. The CK1 substrate peptide RRKDLHDDEEDEAMSITA (J...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Riken Advanced Science Institute

LigandPNGBDBM86373(Juniferdin derivative, 4)
Affinity DataIC50:  627nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227632(MTH1 inhibitor, 53)
Affinity DataIC50:  630nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Riken Advanced Science Institute

LigandPNGBDBM86374(Juniferdin derivative, 5)
Affinity DataIC50:  693nMpH: 7.0Assay Description:Reductase activity was assayed by measuring the PDI-catalyzed reduction of insulin in the presence of DTT, thus measuring the aggregation of reduced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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